Motolese M, Agabiti-Rosei E, Carotti A, Innocenti P, Montervino C, Solinas E, Toso M, Muiesan G
Int J Clin Pharmacol Ther Toxicol. 1980;18(8):332-7.
In a multicentre double-blind study, 92 out-patients with mild to moderate hypertension who had a resting blood pressure greater than or equal to 160/100 mmHg after a two-weeks' placebo wash-out were treated for 6 weeks with a fixed combination of oxprenolol 80 mg + chlorthalidone 10 mg per tablet or chlorthalidone alone (1 tablet = 10 mg). Five patients were drop-outs, 19 out of 44 patients on fixed combination and 7 out of 43 on chlorthalidone were given only 1 tablet b.i.d. throughout the study; the remaining doubled the corresponding dosage after the first 2 weeks. Resting and standing systolic and diastolic blood pressure decreased on both treatments, the reductions being significantly more marked on fixed combination in comparison to chlorthalidone alone (p < 0.01 and p < 0.05). The systolic blood pressure decrease was significantly greater on fixed combination from the first week of treatment (p < 0.05). Normalization of diastolic blood pressure was reached more frequently on fixed combination (73%) than on chlorthalidone (49%) (p < 0.05). Side-effects were recorded in 14 out of 44 patients treated with fixed combination and in 14 out of 43 treated with chlorthalidone. The advantages of treating patients with mild to moderate hypertension with a fixed combination of beta-blocker and diuretics are discussed.
在一项多中心双盲研究中，92例轻度至中度高血压门诊患者在经过两周安慰剂洗脱期后静息血压大于或等于160/100 mmHg，接受了为期6周的治疗，治疗药物为每片含氧烯洛尔80 mg + 氯噻酮10 mg的固定复方制剂或单独使用氯噻酮（1片 = 10 mg）。5例患者退出研究，在整个研究过程中，44例接受固定复方制剂治疗的患者中有19例、43例接受氯噻酮治疗的患者中有7例仅每日两次各服用1片；其余患者在最初2周后将相应剂量加倍。两种治疗方法均使静息和站立时的收缩压和舒张压下降，与单独使用氯噻酮相比，固定复方制剂的降压效果明显更显著（p < 0.01和p < 0.05）。从治疗第一周起，固定复方制剂的收缩压下降幅度就明显更大（p < 0.05）。固定复方制剂组舒张压恢复正常的频率（73%）高于氯噻酮组（49%）（p < 0.05）。44例接受固定复方制剂治疗的患者中有14例记录到副作用，43例接受氯噻酮治疗的患者中有14例记录到副作用。本文讨论了用β受体阻滞剂和利尿剂固定复方制剂治疗轻度至中度高血压患者的优势。
