Robinson Austin A, Ikuta Kevin, Soverow Jonathan
Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
Yale J Biol Med. 2014 Jun 6;87(2):199-206. eCollection 2014 Jun.
Few prospective studies support the use of anticoagulation during the acute phase of ischemic stroke, though observational data suggest a role in certain populations. Depending on the mechanism of stroke, systemic anticoagulation may prevent recurrent cerebral infarction, but concomitantly carries a risk of hemorrhagic transformation. In this article, we describe a case where anticoagulation shows promise for ischemic stroke and review the evidence that has discredited its use in some circumstances while showing its potential in others.
很少有前瞻性研究支持在缺血性中风急性期使用抗凝治疗，尽管观察性数据表明其在某些人群中可能发挥作用。根据中风的机制，全身抗凝治疗可能预防复发性脑梗死，但同时也有出血转化的风险。在本文中，我们描述了一个抗凝治疗对缺血性中风显示出前景的病例，并回顾了一些证据，这些证据在某些情况下否定了其应用，但在其他情况下显示出了其潜力。
