裂谷热的对策开发：主要毒力因子的缺失、修饰或靶向作用
Countermeasure development for Rift Valley fever: deletion, modification or targeting of major virulence factor .
作者信息
Lihoradova Olga, Ikegami Tetsuro
机构信息
Department of Pathology, University of Texas Medical Branch, MMNP3.206D, 301 University Blvd. Galveston, TX 77555-0436, USA.
Department of Pathology, University of Texas Medical Branch, MMNP3.206D, 301 University Blvd. Galveston, TX 77555-0436, USA ; Sealy Center for Vaccine Development, The University of Texas Medical Branch, Galveston, TX, USA ; Center for Biodefense & Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, TX, USA.
出版信息
Future Virol. 2014 Jan 1;9(1):27-39. doi: 10.2217/fvl.13.117.
Abstract
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease characterized by a high rate of abortion in ruminants, and febrile illness, hemorrhagic fever, retinitis and encephalitis in humans. RVF is caused by the RVF virus (RVFV), belonging to the genus of the family . RVFV encodes a major virulence factor, , which is dispensable for viral replication, yet required for evasion of host innate immune responses. RVFV inhibits host gene upregulation at the transcriptional level, while promoting viral translation in the cytoplasm. In this article, we summarize the virology and pathology of RVF, and countermeasure development for RVF, with emphasis on function and applications.
摘要
裂谷热（RVF）是一种由蚊子传播的人畜共患病，其特征是反刍动物流产率高，人类出现发热性疾病、出血热、视网膜炎和脑炎。裂谷热由裂谷热病毒（RVFV）引起，该病毒属于 科的 属。RVFV编码一种主要毒力因子， ，它对于病毒复制不是必需的，但对于逃避宿主先天免疫反应是必需的。RVFV在转录水平抑制宿主基因上调，同时促进病毒在细胞质中的翻译。在本文中，我们总结了裂谷热的病毒学和病理学，以及裂谷热的对策发展，重点是 功能及其应用。
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