三螺旋相互作用蛋白与癌症
Triple helix-interacting proteins and cancer.
作者信息
Van Dyke Mw, Nelson Ld
机构信息
Department of Chemistry and Biochemistry, Kennesaw State University, Kennesaw, Georgia, USA.
Department of Pediatrics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
出版信息
OA Mol Oncol. 2013 Apr 1;1(1):5. doi: 10.13172/2052-9635-1-1-708.
Abstract
While most naturally occurring DNA and RNA adopt the now quite familiar double-helix structure, certain sequences can under the appropriate conditions adopt a three-stranded, triple-helical structure. Both intramolecular and intermolecular triplexes have been described. Evidence for the existence of triplex structures is limited, although cellular proteins have been identified that avidly and specifically interact with such species. The postulated roles of triplexes and the proteins that interact with them in cancer and their potential utility as diagnostic markers are discussed in this review.
摘要
虽然大多数天然存在的DNA和RNA呈现出现在已相当熟悉的双螺旋结构，但某些序列在适当条件下可形成三链的三螺旋结构。分子内和分子间三链体均已被描述。三链体结构存在的证据有限，尽管已鉴定出能与这类结构强烈且特异性相互作用的细胞蛋白。本文综述了三链体及其相互作用蛋白在癌症中的假定作用以及它们作为诊断标志物的潜在用途。
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