父母的杀伤细胞免疫球蛋白样受体（KIR）和胎儿人类白细胞抗原C（HLA-C）基因型与子痫前期风险的相互作用。
Interaction of parental KIR and fetal HLA-C genotypes with the risk of preeclampsia.
作者信息
Yu Hong, Pan Ning, Shen Yang, Jin Shuo, Zhai Jingli, Qiao Dongyan, Shen Yanting, Miao Fengqin, Wang Lina, He Youji, Ren Mulan, Zhang Jianqiong
机构信息
Department of Gynecology and Obstetrics, Affiliated Zhongda Hospital, Medical School, Southeast University , Nanjing, Jiangsu Province , China .
出版信息
Hypertens Pregnancy. 2014 Nov;33(4):402-11. doi: 10.3109/10641955.2014.920026. Epub 2014 Jun 9.
OBJECTIVE
The aim of this study is to investigate whether certain combination of maternal killer cell immunoglobulin-like receptors (KIR) and fetal human leukocyte antigen-C (HLA-C) is risk for preeclampsia in the Chinese Han population.
METHODS
A case-control study was conducted in 47 pregnant women with preeclampsia and 54 normal pregnant women. Twelve KIR genes were genotyped by PCR-sequence-specific primer in mothers. High-resolution HLA-C genotyping was performed in couples and fetuses by a routine sequencing-based typing method.
RESULTS
The frequency of KIR2DS1 was decreased (p = 0.028) and AA genotype was increased (p = 0.017) in preeclampsia compared with controls. More women with KIR AA genotype have fewer C2 genes than their fetuses in preeclampsia than controls.
CONCLUSION
Women with KIR AA genotype and fewer C2 genes than their fetuses were at risk for preeclampsia in the Chinese Han population, supporting that maternal-fetal KIR-HLA-C interaction plays an important role in preeclampsia development.
目的
本研究旨在探讨中国汉族人群中母体杀伤细胞免疫球蛋白样受体（KIR）与胎儿人类白细胞抗原-C（HLA-C）的特定组合是否为子痫前期的危险因素。
方法
对47例子痫前期孕妇和54例正常孕妇进行病例对照研究。采用聚合酶链反应-序列特异性引物法对母亲的12个KIR基因进行基因分型。采用常规测序分型法对夫妇和胎儿进行高分辨率HLA-C基因分型。
结果
与对照组相比，子痫前期患者中KIR2DS1的频率降低（p = 0.028），AA基因型增加（p = 0.017）。与对照组相比，子痫前期中KIR AA基因型的女性比其胎儿拥有更少C2基因的情况更多。
结论
在中国汉族人群中，KIR AA基因型且C2基因比其胎儿少的女性患子痫前期的风险较高，这支持了母胎KIR-HLA-C相互作用在子痫前期发展中起重要作用。
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