Jawdat Dunia, Arab Suha, Thahery Hadeel, Almashaqbeh Walid, Alaskar Ahmed, Hajeer Ali H
Cord Blood Bank, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Transfusion. 2014 Dec;54(12):3127-30. doi: 10.1111/trf.12746. Epub 2014 Jun 9.
Public cord blood banks (CBBs) store cord blood unit (CBU) donations for anyone in need. However, strict regulations need to be followed to build up high-quality bank products that can be used worldwide. We established a public CBB at a tertiary hospital in Saudi Arabia. Here, we investigated the reasons behind rejecting or not collecting CBUs over 2 years (2011-2012) and which steps were implemented to improve the number and quality of storable units.
A total of 2891 mothers were evaluated. Reasons for rejecting donors, not collecting, and rejecting units before or after collection were analyzed and compared for the years 2011 and 2012.
A total of 1157 (40%) CBUs were not collected, mainly due to staff availability, and 564 (20%) CBUs were rejected. The main reason for rejecting donations was the mother's or neonate's health. Rejecting CBUs after collection was due to low volume. A total of 1170 (40%) CBUs were successfully collected for potential banking and sent for processing; however, 58% were rejected in the laboratory due to low total nucleated cell counts. Several changes were implemented during the 2 years including physician education and awareness, in utero collection, cesarean collection, and staff recruitment. These changes positively affected the numbers of our collected units. Out of the initially eligible mothers in 2011, only 17% were banked; this was increased to 33% in 2012.
We identified the problems with collecting CBUs for banking and will keep improving our selection process of recruiting more CBUs of high quality.
公共脐带血库（CBBs）储存脐带血单位（CBU）捐赠品以供任何有需要的人使用。然而，要建立可在全球范围内使用的高质量库产品，需要遵循严格的规定。我们在沙特阿拉伯的一家三级医院建立了一个公共脐带血库。在此，我们调查了2年（2011 - 2012年）期间拒收或未采集CBU的原因，以及为提高可储存单位的数量和质量所采取的措施。
共评估了2891名母亲。分析并比较了2011年和2012年拒收捐赠者、未采集以及采集前后拒收单位的原因。
总共1157个（40%）CBU未被采集，主要原因是人员可用性，564个（20%）CBU被拒收。拒收捐赠的主要原因是母亲或新生儿的健康状况。采集后拒收CBU是因为体积小。总共1170个（40%）CBU被成功采集用于潜在储存并送去处理；然而，58%在实验室因总核细胞计数低而被拒收。在这两年中实施了多项改变，包括医生教育与意识提升、宫内采集、剖宫产采集以及人员招聘。这些改变对我们采集的单位数量产生了积极影响。在2011年最初符合条件的母亲中，只有17%的脐带血被储存；2012年这一比例提高到了33%。
我们确定了采集用于储存的CBU存在的问题，并将持续改进我们的筛选过程，以招募更多高质量的CBU。
