甲氧氯普胺对离体蛙胃和豚鼠回肠蠕动及逆蠕动的作用。
Effect of metoclopramide on peristalsis and antiperistalsis in isolated frog stomach and guinea-pig ileum.
作者信息
Gupta R K, Premendran S J, Sharma M L
机构信息
Department of Pharmacology, MG Institute of Medical Sciences, Wardha, India.
出版信息
Mater Med Pol. 1989 Jul-Sep;21(3):185-8.
The action of metoclopramide was studied on peristaltic as well as antiperistaltic activity in frog stomach and guinea-pig ileum. It was observed that metoclopramide enhances normal peristaltic activity by acting on dopamine-receptors whereas it inhibits antiperistalsis by some unknown mechanism. It is, therefore, inferred that inhibition of antiperistaltic activity might be an additional mechanism for its antiemetic effect. It also explains the pharmacological basis for its use in oesophagitis due to gastro-oesophageal reflux.
研究了胃复安对青蛙胃和豚鼠回肠的蠕动及反蠕动活动的作用。观察到胃复安通过作用于多巴胺受体增强正常蠕动活动，而通过某种未知机制抑制反蠕动。因此，推断抑制反蠕动活动可能是其止吐作用的另一种机制。这也解释了其用于治疗胃食管反流所致食管炎的药理学基础。
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