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Proven value of translational research with appropriate animal models to advance breast cancer treatment and save lives: the tamoxifen tale.利用合适的动物模型进行转化研究以推进乳腺癌治疗并挽救生命的已证实价值：他莫昔芬的故事。
Br J Clin Pharmacol. 2015 Feb;79(2):254-67. doi: 10.1111/bcp.12440.
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Tamoxifen in breast cancer: not so easy to write off.他莫昔芬在乳腺癌治疗中的应用：并非轻易就能摒弃。
Breast. 2008 Apr;17(2):121-4. doi: 10.1016/j.breast.2007.08.010. Epub 2007 Oct 17.
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Tumoristatic action of tamoxifen: experimental evidence for clinical application in stage I and II breast cancer.他莫昔芬的肿瘤抑制作用：Ⅰ期和Ⅱ期乳腺癌临床应用的实验证据
J Chemother. 1989 Jul;1(4 Suppl):1144-7.
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Tamoxifen for early breast cancer.他莫昔芬用于早期乳腺癌。
Nurs Times. 2001;97(25):41.
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Aromatase inhibitors--a triumph of translational oncology.芳香化酶抑制剂——转化肿瘤学的一项成就。
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[Tamoxifen--"golden standard" in the treatment of patients with early breast cancer].他莫昔芬——早期乳腺癌患者治疗的“金标准”
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Tamoxifen as the first targeted long-term adjuvant therapy for breast cancer.他莫昔芬作为乳腺癌的首个靶向长期辅助治疗药物。
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Does hormonal therapy decrease tamoxifen associated hot flashes?激素疗法能减轻他莫昔芬相关的潮热吗？
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Apoptotic index in breast carcinoma cells following tamoxifen treatment.他莫昔芬治疗后乳腺癌细胞的凋亡指数
Int J Gynaecol Obstet. 2006 Oct;95(1):64-5. doi: 10.1016/j.ijgo.2006.05.016. Epub 2006 Jul 7.
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[Tamoxifen and breast cancer: is everything known already?].[他莫昔芬与乳腺癌：一切都已为人所知了吗？]
Tumori. 1998 Nov-Dec;84(6):A1-5.

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Model organism data evolving in support of translational medicine.支持转化医学的模式生物数据演化。
Lab Anim (NY). 2018 Oct;47(10):277-289. doi: 10.1038/s41684-018-0150-4. Epub 2018 Sep 17.
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Establishment of a murine breast tumor model by subcutaneous or orthotopic implantation.通过皮下或原位植入建立小鼠乳腺肿瘤模型。
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Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells.重编程雌激素反应转录组有助于 p53 缺失的乳腺上皮细胞中他莫昔芬依赖的肿瘤发生保护。
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A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.雄激素诱导前列腺癌和乳腺癌细胞凋亡的统一生物学。
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The molecular, cellular and clinical consequences of targeting the estrogen receptor following estrogen deprivation therapy.雌激素剥夺治疗后靶向雌激素受体的分子、细胞及临床后果。
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The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer.雌激素诱导凋亡的新生物学应用于治疗和预防乳腺癌。
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Translational research in oncology--10 years of progress and future prospects.肿瘤学转化研究——十年的进展与未来展望。
Nat Rev Clin Oncol. 2014 Nov;11(11):649-62. doi: 10.1038/nrclinonc.2014.158. Epub 2014 Oct 7.

本文引用的文献

1
Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes.对不同CYP2D6基因型的绝经前乳腺癌患者进行他莫昔芬治疗的体外细胞模拟。
Br J Pharmacol. 2014 Dec;171(24):5624-35. doi: 10.1111/bph.12864.
2
Tamoxifen as the first targeted long-term adjuvant therapy for breast cancer.他莫昔芬作为乳腺癌的首个靶向长期辅助治疗药物。
Endocr Relat Cancer. 2014 May 6;21(3):R235-46. doi: 10.1530/ERC-14-0092. Print 2014 Jun.
3
A(nother) scientific strategy to prevent breast cancer in postmenopausal women by enhancing estrogen-induced apoptosis?通过增强雌激素诱导的细胞凋亡来预防绝经后妇女乳腺癌的另一种科学策略？
Menopause. 2014 Oct;21(10):1160-4. doi: 10.1097/GME.0000000000000220.
4
Defining the conformation of the estrogen receptor complex that controls estrogen-induced apoptosis in breast cancer.定义控制乳腺癌中雌激素诱导凋亡的雌激素受体复合物的构象。
Mol Pharmacol. 2014 May;85(5):789-99. doi: 10.1124/mol.113.089250. Epub 2014 Mar 7.
5
Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells.c-Src 抑制阻断了雌激素诱导的细胞凋亡，并恢复了长期缺乏雌激素的乳腺癌细胞中雌激素刺激的生长。
Eur J Cancer. 2014 Jan;50(2):457-68. doi: 10.1016/j.ejca.2013.10.001. Epub 2013 Oct 30.
6
Prediction of tamoxifen outcome by genetic variation of CYP2D6 in post-menopausal women with early breast cancer.CYP2D6基因变异对绝经后早期乳腺癌女性他莫昔芬治疗结局的预测作用
Br J Clin Pharmacol. 2014 Apr;77(4):695-703. doi: 10.1111/bcp.12229.
7
The value of high adherence to tamoxifen in women with breast cancer: a community-based cohort study.乳腺癌患者高依从性他莫昔芬的价值：一项基于社区的队列研究。
Br J Cancer. 2013 Sep 3;109(5):1172-80. doi: 10.1038/bjc.2013.464. Epub 2013 Aug 15.
8
c-Src modulates estrogen-induced stress and apoptosis in estrogen-deprived breast cancer cells.c-Src 调节雌激素剥夺的乳腺癌细胞中的应激和凋亡。
Cancer Res. 2013 Jul 15;73(14):4510-20. doi: 10.1158/0008-5472.CAN-12-4152. Epub 2013 May 23.
9
Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial.雌激素受体阳性乳腺癌诊断后继续辅助他莫昔芬治疗 10 年与 5 年后停药的长期疗效：ATLAS，一项随机试验。
Lancet. 2013 Mar 9;381(9869):805-16. doi: 10.1016/S0140-6736(12)61963-1.
10
Thalidomide and its sequelae.沙利度胺及其后遗症。
Lancet. 2012 Sep 1;380(9844):781-3. doi: 10.1016/S0140-6736(12)60468-1.

Proven value of translational research with appropriate animal models to advance breast cancer treatment and save lives: the tamoxifen tale.

作者信息

Jordan V Craig

机构信息

Departments of Oncology and Pharmacology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

出版信息

Br J Clin Pharmacol. 2015 Feb;79(2):254-67. doi: 10.1111/bcp.12440.

DOI:10.1111/bcp.12440
PMID:24912921
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4309631/
Abstract
摘要