Shah Binay Kumar, Ghimire Krishna Bilas
Cancer Center and Blood Institute, St. Joseph Regional Medical Center , Lewiston, Idaho , USA.
Acta Oncol. 2014 Jul;53(7):935-8. doi: 10.3109/0284186X.2014.889851. Epub 2014 Mar 10.
Survival in acute myeloid leukemia (AML) has improved in younger patients over the last decade. This study was conducted to evaluate the relative survival rates in older AML patients over two decades in the US.
We analyzed Surveillance, Epidemiology, and End Results (SEER) registry database to evaluate relative survival rate in older (≥ 75 years) AML population diagnosed during 1992-2009. We selected AML patients from 13 registries of SEER 18 database to compare RS during 1992-2000 and 2001-2009.
The relative survival rates improved significantly during 2001-2009 compared to 1992-2000 for all age groups and sex. For young elderly patients (75-84 years) RS increased from 13.1 ± 0.8% to 17.4 ± 0.9% at one year Z-value = 3.98, p < 0.0001 and from 2.0 ± 0.4 to 2.6 ± 0.5%, Z-value = 3.61, p < 0.0005 at five years. Similarly, for very elderly (≥ 85 years) patients RS increased from 5.3 ± 1.0% to 8.0 ± 1.0%, Z-value = 3.03, p < 0.005 at one year, but no improvement seen at five years.
The relative survival in elderly AML has increased significantly during 2001-2009 compared to 1992-2000.
在过去十年中，年轻急性髓系白血病（AML）患者的生存率有所提高。本研究旨在评估美国二十多年来老年AML患者的相对生存率。
我们分析了监测、流行病学和最终结果（SEER）登记数据库，以评估1992 - 2009年期间确诊的老年（≥75岁）AML人群的相对生存率。我们从SEER 18数据库的13个登记处选取AML患者，比较1992 - 2000年和2001 - 2009年期间的相对生存率。
与1992 - 2000年相比，2001 - 2009年期间所有年龄组和性别的相对生存率均显著提高。对于年轻老年患者（75 - 84岁），一年时相对生存率从13.1±0.8%提高到17.4±0.9%，Z值 = 3.98，p < 0.0001；五年时从2.0±0.4%提高到2.6±0.5%，Z值 = 3.61，p < 0.0005。同样，对于高龄（≥85岁）患者，一年时相对生存率从5.3±1.0%提高到8.0±1.0%，Z值 = 3.03，p < 0.005，但五年时未见改善。
与1992 - 2000年相比，2001 - 2009年期间老年AML患者的相对生存率显著提高。
