老年急性髓系白血病患者生存率的提高——一项基于人群的研究。

Improved survival among older acute myeloid leukemia patients - a population-based study.

作者信息

Shah Binay Kumar, Ghimire Krishna Bilas

机构信息

Cancer Center and Blood Institute, St. Joseph Regional Medical Center , Lewiston, Idaho , USA.

出版信息

Acta Oncol. 2014 Jul;53(7):935-8. doi: 10.3109/0284186X.2014.889851. Epub 2014 Mar 10.

DOI:10.3109/0284186X.2014.889851

PMID:24913154

Abstract

BACKGROUND

Survival in acute myeloid leukemia (AML) has improved in younger patients over the last decade. This study was conducted to evaluate the relative survival rates in older AML patients over two decades in the US.

MATERIAL AND METHODS

We analyzed Surveillance, Epidemiology, and End Results (SEER) registry database to evaluate relative survival rate in older (≥ 75 years) AML population diagnosed during 1992-2009. We selected AML patients from 13 registries of SEER 18 database to compare RS during 1992-2000 and 2001-2009.

RESULTS

The relative survival rates improved significantly during 2001-2009 compared to 1992-2000 for all age groups and sex. For young elderly patients (75-84 years) RS increased from 13.1 ± 0.8% to 17.4 ± 0.9% at one year Z-value = 3.98, p < 0.0001 and from 2.0 ± 0.4 to 2.6 ± 0.5%, Z-value = 3.61, p < 0.0005 at five years. Similarly, for very elderly (≥ 85 years) patients RS increased from 5.3 ± 1.0% to 8.0 ± 1.0%, Z-value = 3.03, p < 0.005 at one year, but no improvement seen at five years.

CONCLUSION

The relative survival in elderly AML has increased significantly during 2001-2009 compared to 1992-2000.

摘要

背景

在过去十年中，年轻急性髓系白血病（AML）患者的生存率有所提高。本研究旨在评估美国二十多年来老年AML患者的相对生存率。

材料与方法

我们分析了监测、流行病学和最终结果（SEER）登记数据库，以评估1992 - 2009年期间确诊的老年（≥75岁）AML人群的相对生存率。我们从SEER 18数据库的13个登记处选取AML患者，比较1992 - 2000年和2001 - 2009年期间的相对生存率。

结果

与1992 - 2000年相比，2001 - 2009年期间所有年龄组和性别的相对生存率均显著提高。对于年轻老年患者（75 - 84岁），一年时相对生存率从13.1±0.8%提高到17.4±0.9%，Z值 = 3.98，p < 0.0001；五年时从2.0±0.4%提高到2.6±0.5%，Z值 = 3.61，p < 0.0005。同样，对于高龄（≥85岁）患者，一年时相对生存率从5.3±1.0%提高到8.0±1.0%，Z值 = 3.03，p < 0.005，但五年时未见改善。