Koh Min Jung, Jeung Hei-Cheul, Namkoong Kee, Chung Hyun Cheol, Kang Jee In
Department of Psychiatry, Yonsei University College of Medicine, Seoul, South Korea; The Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Division of Oncology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei Cancer Center, Yonsei Cancer Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
J Psychosom Res. 2014 Jul;77(1):76-80. doi: 10.1016/j.jpsychores.2014.04.008. Epub 2014 May 5.
Coping with cancer is an important determinant of psychological morbidity, quality of life, and treatment adherence in cancer patients. The aim of this study was to elucidate the association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and coping response to stress in patients diagnosed with advanced gastric cancer.
Ninety-one subjects (60 males, 31 females) recently diagnosed with advanced gastric cancer were recruited. Coping style and distress level were examined using the Mini-Mental Adjustment to Cancer (Mini-MAC) scale and Hospital Anxiety and Depression Scale, and genotyping was evaluated. To examine the temporal stability of the Mini-MAC scores, a 6-week follow-up evaluation was conducted in 72 patients, after completion of two chemotherapy cycles.
Coping style to cancer significantly differed between the Met carriers of BDNF Val66Met and the Val/Val homozygotes. The Met carriers were significantly more anxious than the Val/Val homozygotes.
The present findings suggest that the BDNF Val66Met polymorphism may be involved in individual coping responses to cancer. The Met allele of BDNF Val66Met may be predictive of an anxious coping style in patients with advanced cancer.
应对癌症是癌症患者心理发病率、生活质量和治疗依从性的重要决定因素。本研究的目的是阐明脑源性神经营养因子（BDNF）Val66Met多态性与晚期胃癌患者应激应对反应之间的关联。
招募了91名近期诊断为晚期胃癌的受试者（60名男性，31名女性）。使用癌症心理适应简易量表（Mini-MAC）和医院焦虑抑郁量表检查应对方式和痛苦程度，并进行基因分型评估。为了检查Mini-MAC评分的时间稳定性，在72名患者完成两个化疗周期后进行了为期6周的随访评估。
BDNF Val66Met的Met携带者与Val/Val纯合子之间对癌症的应对方式存在显著差异。Met携带者比Val/Val纯合子明显更焦虑。
目前的研究结果表明，BDNF Val66Met多态性可能参与个体对癌症的应对反应。BDNF Val66Met的Met等位基因可能预示晚期癌症患者的焦虑应对方式。
