de Vries McClintock Heather F, Morales Knashawn H, Small Dylan S, Bogner Hillary R
Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA, USA,
J Behav Med. 2015 Feb;38(1):39-47. doi: 10.1007/s10865-014-9576-3. Epub 2014 Jun 10.
This study examined whether longitudinal adherence profiles mediated the relationship between a brief adherence intervention and glycemic control among patients with type 2 diabetes. Adherence was assessed using the Medication Event Monitoring System. Longitudinal analysis via growth curve mixture modeling was carried out to classify patients according to patterns of adherence to oral hypoglycemic agents. Hemoglobin A1c assays were used to measure glycemic control as the clinical outcome. Across the whole sample, longitudinal adherence profiles mediated 35.2% (13.2, 81.0%) of the effect of a brief adherence intervention on glycemic control [from odds ratio (OR) = 8.48, 95% confidence interval (CI) (3.24, 22.2) to 4.00, 95% CI (1.34, 11.93)]. Our results suggest that patients in the intervention had better glycemic control largely due to their greater likelihood of adherence to oral hypoglycemic agents.
本研究调查了纵向依从性概况是否介导了2型糖尿病患者简短依从性干预与血糖控制之间的关系。使用药物事件监测系统评估依从性。通过生长曲线混合模型进行纵向分析，以根据口服降糖药的依从模式对患者进行分类。采用糖化血红蛋白检测来测量血糖控制情况作为临床结局。在整个样本中，纵向依从性概况介导了简短依从性干预对血糖控制效果的35.2%（13.2，81.0%）[从优势比（OR）=8.48，95%置信区间（CI）（3.24，22.2）降至4.00，95%CI（1.34，11.93）]。我们的结果表明，干预组患者血糖控制更好，很大程度上是因为他们更有可能坚持服用口服降糖药。
