Coffin Samuel T, Raj Satish R
Autonomic Dysfunction Center, Vanderbilt University School of Medicine; Departments of Medicine, Vanderbilt University School of Medicine.
Autonomic Dysfunction Center, Vanderbilt University School of Medicine; Departments of Medicine, Vanderbilt University School of Medicine; Department of Pharmacology, Vanderbilt University School of Medicine.
Auton Neurosci. 2014 Sep;184:77-82. doi: 10.1016/j.autneu.2014.05.009. Epub 2014 May 27.
Vasovagal Syncope (VVS) can lead to a markedly diminished quality of life for some patients. While there are many treatments for this condition including physical, mechanical, pharmacologic, and device-based control of heart rate, there are few that have been shown to be effective in randomized clinical trials. In our local experience, we have achieved significant improvement in symptom frequency and quality of life using algorithms based on the data available and on clinical acumen for the majority of patients with VVS. Despite this, there are still many patients who suffer from treatment refractory VVS. Fortunately, there are a number of ongoing clinical trials that are likely to add to our knowledge. Ongoing clinical trials are reviewed to examine new treatment methods for VVS that were listed on public trial registries as of April 15, 2014. Data from these trials should inform future strategies in the care of patients with VVS.
血管迷走性晕厥（VVS）会导致部分患者的生活质量显著下降。虽然针对这种病症有多种治疗方法，包括对心率进行物理、机械、药物及基于设备的控制，但在随机临床试验中被证明有效的方法却很少。根据我们当地的经验，对于大多数VVS患者，我们利用基于现有数据和临床敏锐度的算法，在症状发生频率和生活质量方面取得了显著改善。尽管如此，仍有许多患者患有难治性VVS。幸运的是，目前有多项正在进行的临床试验，可能会增加我们的相关知识。本文对正在进行的临床试验进行综述，以研究截至2014年4月15日在公共试验登记处列出的VVS新治疗方法。这些试验的数据应为未来VVS患者的护理策略提供参考。
