Sui Lu, Liu Kun, Shen Wei, Zhang Liang
Department of Pathophysiology, Shenyang Medical College, Huanghe North Avenue No.146, Shenyang, 110034, People's Republic of China,
Tumour Biol. 2014 Sep;35(9):9085-93. doi: 10.1007/s13277-014-2173-9. Epub 2014 Jun 11.
We carried out the current meta-analysis of relevant cohort studies in an attempt to investigate the relationships between vascular endothelial growth factor (VEGF) expression and pathological characteristics of diffuse large B cell lymphoma (DLBCL). The following electronic databases were searched for relevant articles without any language restrictions: Web of Science (1945 ~ 2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966 ~ 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013). Meta-analyses were conducted with the use of STATA software (version 12.0, Stata Corporation, College Station, TX, USA). Odds ratios (ORs) and its 95 % confidence interval (95 % CI) were calculated. Nine clinical cohort studies with a total of 789 DLBCL patients met our inclusion criteria. The meta-analysis results showed that patients with positive VEGF expression had higher international prognostic index (IPI) scores than VEGF-negative patients (OR = 5.12, 95 % CI = 2.70 ~ 9.71, P < 0.001). There was a significantly positive association between positive VEGF expression and evaluated lactate dehydrogenase (LDH) levels (OR = 2.50, 95 % CI = 1.36 ~ 4.60, P = 0.003). We also found that patients with positive B symptoms had increased level of VEGF expression (OR = 2.02, 95 % CI = 1.08 ~ 3.77, P = 0.027). The findings of our meta-analysis provide reliable evidence that VEGF expression may be strongly correlated with pathological characteristics of DLBCL.
我们对相关队列研究进行了当前的荟萃分析，旨在探究血管内皮生长因子（VEGF）表达与弥漫性大B细胞淋巴瘤（DLBCL）病理特征之间的关系。我们检索了以下电子数据库中的相关文章，无任何语言限制：科学引文索引（1945年至2013年）、考克兰图书馆数据库（2013年第12期）、医学期刊数据库（1966年至2013年）、荷兰医学文摘数据库（1980年至2013年）、护理学与健康领域数据库（1982年至2013年）以及中国生物医学文献数据库（CBM）（1982年至2013年）。使用STATA软件（版本12.0，美国德克萨斯州大学站市Stata公司）进行荟萃分析。计算优势比（OR）及其95%置信区间（95%CI）。九项临床队列研究共纳入789例DLBCL患者，符合我们的纳入标准。荟萃分析结果显示，VEGF表达阳性的患者国际预后指数（IPI）得分高于VEGF表达阴性的患者（OR = 5.12，95%CI = 2.70至9.71，P < 0.001）。VEGF表达阳性与评估的乳酸脱氢酶（LDH）水平之间存在显著正相关（OR = 2.50，95%CI = 1.36至4.60，P = 0.003）。我们还发现有B症状的患者VEGF表达水平升高（OR = 2.02，95%CI = 1.08至3.77，P = 0.027）。我们的荟萃分析结果提供了可靠证据，表明VEGF表达可能与DLBCL的病理特征密切相关。
