Yuan Quan, Sun Li, Li Jian-Jun, An Chun-Hou
Department of Orthopedics, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping District, Shenyang, 110004, P.R. China.
Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, P.R. China.
BMC Musculoskelet Disord. 2014 Dec 17;15:437. doi: 10.1186/1471-2474-15-437.
The aim of our meta-analysis is to understand the relationship between the pathogenesis of osteoarthritis and the expression levels of vascular endothelial growth factor (VEGF) in multiple disease tissues in osteoarthritis patients.
The following electronic databases were searched, without language restrictions, to retrieve published studies relevant to VEGF and osteoarthritis: MEDLINE (1966 ~ 2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), Web of Science (1945 ~ 2013) and the Chinese Biomedical Database (CBM) (1982 ~ 2013). Meta-analysis of the extracted data was performed using the STATA statistical software. Standardized mean difference (SMD) with its corresponding 95% confidence interval (95% CI) was calculated.
A total of 11 case-control studies, containing 302 osteoarthritis patients and 195 healthy controls, met our selection criteria for this meta-analysis. Our analyses of the data available from multiple disease tissues demonstrate that VEGF expression levels in osteoarthritis patients are significantly higher than healthy controls (SMD = 1.18, 95% CI: 4.91 ~ 9.11, P < 0.001). A subgroup analysis based on ethnicity revealed that both Asian and Caucasian osteoarthritis patients had higher levels of VEGF expression compared to their respective healthy counterparts (Asians: SMD = 5.49, 95% CI: 3.44 ~ 7.54, P < 0.001; Caucasians: SMD = 15.17, 95% CI: 5.21 ~ 25.13, P = 0.003; respectively). We also performed other subgroup analyses based on country, language and sample source, and the results showed that, in all these subgroups, osteoarthritis patients had higher levels of VEGF expression than healthy controls (all P > 0.05).
Our meta-analysis provides evidence that higher VEGF expression levels strongly correlate with the pathogenesis of osteoarthritis.
我们进行这项荟萃分析的目的是了解骨关节炎发病机制与骨关节炎患者多种疾病组织中血管内皮生长因子（VEGF）表达水平之间的关系。
检索了以下电子数据库，无语言限制，以获取与VEGF和骨关节炎相关的已发表研究：MEDLINE（1966年至2013年）、Cochrane图书馆数据库（2013年第12期）、EMBASE（1980年至2013年）、CINAHL（1982年至2013年）、科学网（1945年至2013年）和中国生物医学数据库（CBM）（1982年至2013年）。使用STATA统计软件对提取的数据进行荟萃分析。计算标准化均数差（SMD）及其相应的95%置信区间（95%CI）。
共有11项病例对照研究符合我们这项荟萃分析的纳入标准，其中包括302例骨关节炎患者和195例健康对照。我们对来自多种疾病组织的现有数据进行分析，结果表明骨关节炎患者的VEGF表达水平显著高于健康对照（SMD = 1.18，95%CI：4.91至9.11，P < 0.001）。基于种族的亚组分析显示，与各自的健康对照相比，亚洲和白种人的骨关节炎患者VEGF表达水平均较高（亚洲人：SMD = 5.49，95%CI：3.44至7.54，P < 0.001；白种人：SMD = 15.17，95%CI：5.21至25.13，P = 0.003）。我们还基于国家、语言和样本来源进行了其他亚组分析，结果显示，在所有这些亚组中，骨关节炎患者的VEGF表达水平均高于健康对照（所有P > 0.05）。
我们的荟萃分析提供了证据，表明较高的VEGF表达水平与骨关节炎的发病机制密切相关。
