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Correlation between chemosensitivity to anticancer drugs and telomerase reverse transcriptase mRNA expression in gastric cancer.胃癌中抗癌药物的化疗敏感性与端粒酶逆转录酶 mRNA 表达的相关性。
Diagn Pathol. 2013 Feb 22;8:33. doi: 10.1186/1746-1596-8-33.
2
Circulating cell-free human telomerase reverse transcriptase mRNA in plasma and its potential diagnostic and prognostic value for gastric cancer.循环游离人端粒酶逆转录酶 mRNA 在血浆中的表达及其对胃癌的诊断和预后价值。
Int J Clin Oncol. 2013 Jun;18(3):478-86. doi: 10.1007/s10147-012-0405-9. Epub 2012 Apr 12.
3
Is telomerase a viable target in cancer?端粒酶在癌症中是否是一个可行的靶点？
Mutat Res. 2012 Feb 1;730(1-2):90-7. doi: 10.1016/j.mrfmmm.2011.07.006. Epub 2011 Jul 23.
4
Prevalence of telomerase activity in human cancer.端粒酶活性在人类癌症中的流行率。
J Formos Med Assoc. 2011 May;110(5):275-89. doi: 10.1016/S0929-6646(11)60043-0.
5
Telomerase as an emerging target to fight cancer--opportunities and challenges for nanomedicine.端粒酶作为抗癌的新兴靶点——纳米医学的机遇与挑战。
J Control Release. 2010 Sep 1;146(2):228-40. doi: 10.1016/j.jconrel.2010.03.025. Epub 2010 Apr 8.
6
hTERT methylation and expression in gastric cancer.胃癌中 hTERT 的甲基化与表达。
Biomarkers. 2009 Dec;14(8):630-6. doi: 10.3109/13547500903225912.
7
Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues.全长端粒酶逆转录酶（hTERT）转录本在恶性和正常胃组织中的表达。
Cancer Lett. 2008 Feb 18;260(1-2):28-36. doi: 10.1016/j.canlet.2007.10.018. Epub 2007 Nov 26.
8
Circulating cell-free mRNA in plasma as a tumor marker for patients with primary and recurrent gastric cancer.血浆中循环游离mRNA作为原发性和复发性胃癌患者的肿瘤标志物
Anticancer Res. 2007 Mar-Apr;27(2):1207-12.
9
Telomerase activity and human telomerase reverse transcriptase expression in colorectal carcinoma.端粒酶活性及人端粒酶逆转录酶在结直肠癌中的表达
World J Gastroenterol. 2006 Jan 21;12(3):465-7. doi: 10.3748/wjg.v12.i3.465.
10
Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telomerase reverse transcriptase expression/telomerase activation induced by proliferation.丝裂原活化蛋白激酶级联介导的组蛋白H3磷酸化对于增殖诱导的端粒酶逆转录酶表达/端粒酶激活至关重要。
Mol Cell Biol. 2006 Jan;26(1):230-7. doi: 10.1128/MCB.26.1.230-237.2006.

端粒酶与人类端粒酶逆转录酶：它们能否作为胃癌诊断的标志物？

Telomerase and hTERT: can they serve as markers for gastric cancer diagnosis?

作者信息

Cheng Yong-Bo, Guo Li-Ping, Yao Ping, Ning Xiao-Yan, Aerken Gulimire, Fang Dian-Chun

机构信息

Yong-Bo Cheng, Ping Yao, Gulimire∙Aerken, Department of Gastroenterology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China.

出版信息

World J Gastroenterol. 2014 Jun 7;20(21):6615-9. doi: 10.3748/wjg.v20.i21.6615.

DOI:10.3748/wjg.v20.i21.6615
PMID:24914385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4047349/
Abstract

AIM

To investigate telomerase activity and human telomerase reverse transcriptase (hTERT) expression in normal human gastric mucosal epithelial cells (nhGMECs) and fibroblasts (nhGMFs).

METHODS

nhGMECs and nhGMFs were isolated and cultured from specimens obtained during routine surgery for bleeding peptic ulcer. Telomerase activity in nhGMFs, nhGMECs, and the tumor cell lines BGC-823, SGC-7901 and MKN-28 cells was analyzed using the telomeric repeat amplification protocol assay. hTERT protein was determined in nhGMECs, nhGMFs, BGC-823, SGC-7901 and MKN-28 cells by indirect immunofluorescence.

RESULTS

A similar level of telomerase activity was observed in nhGMECs, nhGMFs and BGC-823, SGC-7901, MKN-28 cell lines. Positive hTERT immunostaining was detected in nhGMECs, nhGMFs, BGC-823, SGC-7901 and MKN-28 cell lines.

CONCLUSION

The use of telomerase or hTERT as diagnostic markers for gastric cancer may require further studies.

摘要

目的

研究正常人胃黏膜上皮细胞（nhGMECs）和成纤维细胞（nhGMFs）中的端粒酶活性及人端粒酶逆转录酶（hTERT）表达。

方法

从因消化性溃疡出血接受常规手术获取的标本中分离并培养nhGMECs和nhGMFs。采用端粒重复序列扩增法分析nhGMFs、nhGMECs以及肿瘤细胞系BGC - 823、SGC - 7901和MKN - 28细胞中的端粒酶活性。通过间接免疫荧光法测定nhGMECs、nhGMFs、BGC - 823、SGC - 7901和MKN - 28细胞中的hTERT蛋白。

结果

在nhGMECs、nhGMFs以及BGC - 823、SGC - 7901、MKN - 28细胞系中观察到相似水平的端粒酶活性。在nhGMECs、nhGMFs、BGC - 823、SGC - 7901和MKN - 28细胞系中检测到hTERT免疫染色阳性。

结论

将端粒酶或hTERT用作胃癌诊断标志物可能需要进一步研究。