维生素 C 治疗高铁血红蛋白血症：一家大型三级儿科医院的经验。
Ascorbic acid for the treatment of methemoglobinemia: the experience of a large tertiary care pediatric hospital.
机构信息
1Division of Pediatric Emergency Medicine, Hospital de Pediatría Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina; 2Division of Pediatric Emergency Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada; 3Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Ontario, Canada; 4Division of Pediatric Emergency Medicine, Department of Pediatrics, Dana-Dwek Children Hospital, University of Tel Aviv, Tel Aviv, Israel; and 5Division of Clinical Pharmacology and Toxicology, Ichilov Hospital, University of Tel Aviv, Tel Aviv, Israel.
出版信息
Am J Ther. 2014 Jul-Aug;21(4):240-3. doi: 10.1097/MJT.0000000000000028.
The purpose of reporting this series of patients is to illustrate the role of ascorbic acid in the treatment of severe acquired methemoglobinemia (metHb), especially when methylene blue is not available. Medical records of affected patients were reviewed to collect history of exposures, food ingestion, physical examination, pulse oximetry, blood gas, and co-oximetry results, and outcomes. Five cases of acquired metHb are presented here, all of whom received treatment with ascorbic acid and fully recovered after 24 hours of treatment. Our series emphasizes that ascorbic acid is an effective alternative in the management of acquired metHb if methylene blue is unavailable and suggests that ascorbic acid infusion may be indicated in patients with glucose-6-phosphatase dehydrogenase deficiency.
报告这一系列病例的目的是说明抗坏血酸在治疗严重获得性高铁血红蛋白血症（metHb）中的作用，特别是在亚甲蓝不可用时。回顾了受影响患者的病历，以收集暴露史、食物摄入、体检、脉搏血氧饱和度、血气和协同氧合结果以及结局。本文介绍了 5 例获得性 metHb 病例，所有患者均接受抗坏血酸治疗，治疗 24 小时后完全康复。我们的系列研究强调，如果没有亚甲蓝，抗坏血酸是治疗获得性 metHb 的有效替代方法，并表明在葡萄糖-6-磷酸脱氢酶缺乏的患者中，抗坏血酸输注可能是指征。
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