Suppr超能文献

一名癌症患者因多种药物联用引发血清素综合征的病例研究。

A Case study of polypharmacy-induced serotonin syndrome in a cancer patient.

作者信息

Zhu Andrew, Kuhnly Nicole, Chen Leon, Dulu Alina O

机构信息

Department of Anesthesiology & Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Columbia University School of Nursing, New York, New York.

出版信息

J Am Assoc Nurse Pract. 2024 Dec 1;36(12):728-732. doi: 10.1097/JXX.0000000000001048.

Abstract

Polypharmacy in cancer care can be complex and detrimental, particularly among younger patients, who can be easily overlooked. This report showcases a 54-year-old woman with cancer, treated for dapsone-induced methemoglobinemia with methylene blue (MB), subsequently developing serotonin syndrome (SS) due to concurrent serotonin-active medications. This case highlights the critical impact of polypharmacy, emphasizing the necessity for acute care providers to diligently assess medication interactions, especially in emergencies. It underscores the importance of considering alternative treatments and the vigilant monitoring of symptoms indicative of adverse drug interactions to ensure patient safety and optimize outcomes in complex therapeutic scenarios.

摘要

癌症治疗中的多重用药可能很复杂且有害,尤其是在年轻患者中,他们很容易被忽视。本报告展示了一名54岁的癌症女性患者,因服用氨苯砜导致高铁血红蛋白血症而接受亚甲蓝(MB)治疗,随后因同时使用5-羟色胺活性药物而发生5-羟色胺综合征(SS)。该病例突出了多重用药的关键影响,强调了急症护理人员认真评估药物相互作用的必要性,尤其是在紧急情况下。它强调了考虑替代治疗方法以及密切监测表明药物不良反应的症状的重要性,以确保患者安全并在复杂的治疗场景中优化治疗效果。

相似文献

1
A Case study of polypharmacy-induced serotonin syndrome in a cancer patient.
J Am Assoc Nurse Pract. 2024 Dec 1;36(12):728-732. doi: 10.1097/JXX.0000000000001048.
3
Acquired methemoglobinemia induced by dapsone in a 16-year-old female: A case report from Iraq-A case report.
Medicine (Baltimore). 2025 Jul 25;104(30):e41991. doi: 10.1097/MD.0000000000041991.
4
Co-occurrence of acute hemolytic anemia and methemoglobinemia in a 74-year-old female with G6PD deficiency: A case report.
Medicine (Baltimore). 2025 Jun 13;104(24):e42826. doi: 10.1097/MD.0000000000042826.
5
Linezolid in combination with pentazocine causes serotonin syndrome: A case report.
Medicine (Baltimore). 2025 Jul 18;104(29):e43517. doi: 10.1097/MD.0000000000043517.
6
Antipsychotic polypharmacy reduction versus polypharmacy continuation for people with schizophrenia.
Cochrane Database Syst Rev. 2022 Aug 30;8(8):CD014383. doi: 10.1002/14651858.CD014383.pub2.
7
Interventions to improve the appropriate use of polypharmacy for older people.
Cochrane Database Syst Rev. 2018 Sep 3;9(9):CD008165. doi: 10.1002/14651858.CD008165.pub4.
8
Interventions to improve the appropriate use of polypharmacy for older people.
Cochrane Database Syst Rev. 2023 Oct 11;10(10):CD008165. doi: 10.1002/14651858.CD008165.pub5.
9
Severe Treatment-Resistant Methemoglobinemia of Unknown Etiology With Recurrence.
Case Rep Crit Care. 2025 Jun 17;2025:5740399. doi: 10.1155/crcc/5740399. eCollection 2025.
10
Management of urinary stones by experts in stone disease (ESD 2025).
Arch Ital Urol Androl. 2025 Jun 30;97(2):14085. doi: 10.4081/aiua.2025.14085.

引用本文的文献

1
Advancing drug-drug interactions research: integrating AI-powered prediction, vulnerable populations, and regulatory insights.
Front Pharmacol. 2025 Aug 13;16:1618701. doi: 10.3389/fphar.2025.1618701. eCollection 2025.

本文引用的文献

2
Methylene Blue Infusion to Treat Severe Dapsone-Induced Methemoglobinemia in a Pediatric Patient.
Cureus. 2021 Oct 18;13(10):e18853. doi: 10.7759/cureus.18853. eCollection 2021 Oct.
3
Recommendations for diagnosis and treatment of methemoglobinemia.
Am J Hematol. 2021 Dec 1;96(12):1666-1678. doi: 10.1002/ajh.26340. Epub 2021 Sep 23.
5
Serotonin Syndrome: Pathophysiology, Clinical Features, Management, and Potential Future Directions.
Int J Tryptophan Res. 2019 Sep 9;12:1178646919873925. doi: 10.1177/1178646919873925. eCollection 2019.
6
Polypharmacy and patterns of prescription medication use among cancer survivors.
Cancer. 2018 Jul 1;124(13):2850-2857. doi: 10.1002/cncr.31389. Epub 2018 Apr 12.
7
Role of Automated Therapeutic Red Cell Exchange in the Setting of Acute Methemoglobinemia: Our Experience.
Indian J Hematol Blood Transfus. 2018 Jan;34(1):143-145. doi: 10.1007/s12288-017-0832-x. Epub 2017 May 22.
9
Polypharmacy and Medication Management in Older Adults.
Nurs Clin North Am. 2017 Sep;52(3):457-468. doi: 10.1016/j.cnur.2017.04.007.
10
Plasmapheresis in severe methemoglobinemia following occupational exposure.
Transfus Apher Sci. 2017 Jun;56(3):341-344. doi: 10.1016/j.transci.2017.02.003. Epub 2017 Feb 20.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验