Gonzales Gustavo F, Tapia Vilma
J Basic Clin Physiol Pharmacol. 2015 Jan;26(1):81-7. doi: 10.1515/jbcpp-2013-0162.
Currently there are no studies on γ-glutamyltransferase (γGT) levels at high altitude or on the relationship between γGT, uric acid and several dysfunctions. The aim of the study was to determine the association between serum γGT and uric acid levels in subjects at high altitude with hemoglobin, glycemia, and lipidic, hepatic and kidney markers.
The present study was performed in 487 subjects aged 30-75 years living at 4100 m of altitude. A venous blood sample was drawn from each subject to measure hemoglobin, glucose, and lipid levels and markers of liver and kidney function. Quartiles for serum γGT and uric acid were calculated and associated with different physiological variables. A p-value <0.05 was considered statistically significant.
Serum γGT values were higher in men (38.35± 2.54 IU/L) than in women (30.33±1.76 IU/L) (p<0.01). Similarly, serum uric acid levels were higher in men (5.78± 0.12 mg/dL) than in women (4.29±0.08 mg/dL; p<0.001). Serum γGT levels in the top quartile were associated with higher glycemia, overweight/obesity, increased levels of non-high-density lipoprotein (non-HDL) cholesterol, triglycerides, alanine aminotransferase, alkaline phosphatase, uric acid, creatinine, and hemoglobin. Levels of uric acid in the top quartile were associated with overweight/obesity, elevated non-HDL cholesterol, triglycerides, creatinine, γGT and hemoglobin. Higher arterial blood pressure was associated with high levels of uric acid but not with γGT levels.
At high altitude, increased γGT levels were associated with hyperglycemia; increased uric acid levels were associated with overweight/obesity, hemoglobin, dyslipidemia, high blood pressure and kidney disease.
目前尚无关于高海拔地区γ-谷氨酰转移酶（γGT）水平，或γGT、尿酸与多种功能障碍之间关系的研究。本研究的目的是确定高海拔地区受试者血清γGT与尿酸水平，与血红蛋白、血糖、脂质、肝脏和肾脏标志物之间的关联。
本研究对487名年龄在30 - 75岁、生活在海拔4100米的受试者进行。采集每位受试者的静脉血样本，以测量血红蛋白、葡萄糖、脂质水平以及肝脏和肾脏功能标志物。计算血清γGT和尿酸的四分位数，并将其与不同的生理变量相关联。p值<0.05被认为具有统计学意义。
男性血清γGT值（38.35±2.54 IU/L）高于女性（30.33±1.76 IU/L）（p<0.01）。同样，男性血清尿酸水平（5.78±0.12 mg/dL）高于女性（4.29±0.08 mg/dL；p<0.001）。最高四分位数的血清γGT水平与更高的血糖、超重/肥胖、非高密度脂蛋白（non-HDL）胆固醇、甘油三酯、丙氨酸转氨酶、碱性磷酸酶、尿酸、肌酐和血红蛋白水平相关。最高四分位数的尿酸水平与超重/肥胖、非HDL胆固醇升高、甘油三酯、肌酐、γGT和血红蛋白相关。较高的动脉血压与高尿酸水平相关，但与γGT水平无关。
在高海拔地区，γGT水平升高与高血糖相关；尿酸水平升高与超重/肥胖、血红蛋白、血脂异常、高血压和肾脏疾病相关。
