Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Clin Endocrinol (Oxf). 2011 Sep;75(3):328-34. doi: 10.1111/j.1365-2265.2011.04060.x.
Gamma-glutamyltransferase (GGT) has been reported to be useful in predicting cardiovascular disease. Arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) is not only a marker of vascular damage but a significant predictor of cardiovascular events. Gender difference has been reported in the association between GGT and baPWV. We assessed, therefore, the association between GGT and baPWV in a large population and determined whether there was gender difference.
This cross-sectional study was conducted at the Asan Medical Centre, Seoul, Republic of Korea.
Serum GGT, baPWV and conventional risk factors were measured in 10 988 apparently healthy subjects (7248 men, 3740 women) who participated in a routine health screening examination.
In both men and women, we observed positive linearity between GGT quartiles and body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, LDL cholesterol, triglycerides, uric acid, high-sensitive C-reactive protein (hsCRP) and homeostatic model assessment of insulin resistance (HOMA-IR) score (P for trends < 0·001). The proportion of individuals with diabetes, hypertension increased as the GGT quartile increased (P for trends < 0·001). Age-adjusted mean baPWV increased gradually in both males and females according to GGT quartiles (P for trends < 0·001 in both genders). The odds for higher baPWV (i.e. >75th percentile in each sex) were significantly higher in the highest compared with the lowest GGT quartiles, after adjustment for confounding variables, in both men [odds ratio (OR) = 1·63, 95% CI = 1·21-2·20] and women (OR = 1·56, 95% CI = 1·08-2·27).
These results suggest that GGT is independently associated with the increased level of arterial stiffness both in men and in women and the association between them appears to be stronger in men compared to women.
γ-谷氨酰转移酶（GGT）已被证明可用于预测心血管疾病。肱踝脉搏波速度（baPWV）测量的动脉僵硬度不仅是血管损伤的标志物，也是心血管事件的重要预测指标。已有研究报道 GGT 与 baPWV 之间的相关性存在性别差异。因此，我们在一个大人群中评估了 GGT 与 baPWV 之间的相关性，并确定了这种相关性是否存在性别差异。
本横断面研究在韩国首尔的 Asan 医疗中心进行。
10988 名看似健康的受试者（7248 名男性，3740 名女性）参加了常规健康筛查检查，测量了血清 GGT、baPWV 和常规危险因素。
在男性和女性中，我们观察到 GGT 四分位与体重指数、腰围、收缩压、舒张压、空腹血糖、总胆固醇、LDL 胆固醇、甘油三酯、尿酸、高敏 C 反应蛋白（hsCRP）和稳态模型评估的胰岛素抵抗（HOMA-IR）评分呈正线性关系（趋势 P<0·001）。随着 GGT 四分位数的增加，糖尿病和高血压患者的比例也逐渐增加（趋势 P<0·001）。在男性和女性中，根据 GGT 四分位数，年龄校正后的平均 baPWV 逐渐升高（两性趋势 P<0·001）。与最低 GGT 四分位相比，最高 GGT 四分位的 baPWV 更高（即每个性别超过第 75 百分位数）的可能性显著更高，在校正混杂因素后，男性[比值比（OR）=1·63，95%置信区间（CI）=1·21-2·20]和女性（OR=1·56，95%CI=1·08-2·27）。
这些结果表明，GGT 与男性和女性动脉僵硬度的升高水平独立相关，且男性的相关性似乎强于女性。
