Department of Chemistry, State Key Lab of Molecular Engineering of Polymers and Institutes of Biomedical Sciences, Fudan University , Shanghai 200433, China.
Anal Chem. 2014 Jul 1;86(13):6660-5. doi: 10.1021/ac501383x. Epub 2014 Jun 23.
Surface-enhanced Raman scattering (SERS) has proven to be promising for the detection of trace analytes; however, the precise nanofabrication of a specific and sensitive plasmonic SERS-active substrate is still a major challenge that limits the scope of its applications. In this work, gold nanoparticles are self-assembled into densely packed two-dimensional arrays at a liquid/liquid interface between dimethyl carbonate and water in the absence of template controller molecules. Both the simulation and experiment results show that the particles within these film-like arrays exhibit strong electromagnetic coupling and enable large amplification of Raman signals. In order to realize the level of sensing specificity, the surface chemistry of gold nanoparticles (Au NPs) is rationally tailored by incorporating an appropriate chemical moiety that specifically captures molecules of interest. The ease of fabrication and good uniformity make this platform ideal for in situ SERS sensing of trace targets in complex samples.
表面增强拉曼散射（SERS）已被证明是痕量分析物检测的一种很有前途的方法；然而，精确地纳米制造特定且灵敏的等离子体 SERS 活性衬底仍然是一个主要挑战，限制了其应用范围。在这项工作中，在没有模板控制器分子的情况下，金纳米粒子在碳酸二甲酯和水之间的液/液界面自组装成密集的二维阵列。模拟和实验结果都表明，这些薄膜状阵列中的粒子表现出强烈的电磁耦合，并能够大大放大拉曼信号。为了实现传感特异性的水平，通过合理地引入适当的化学基团来修饰金纳米粒子（Au NPs）的表面化学性质，从而特异性地捕获感兴趣的分子。这种平台易于制造且具有良好的均匀性，非常适合复杂样品中痕量目标的原位 SERS 传感。
