一种基于金纳米孔阵列的表面增强拉曼散射生物传感器，用于检测人类唾液中的银（I）和汞（II）。
A gold nanohole array based surface-enhanced Raman scattering biosensor for detection of silver(I) and mercury(II) in human saliva.
作者信息
Zheng Peng, Li Ming, Jurevic Richard, Cushing Scott K, Liu Yuxin, Wu Nianqiang
机构信息
Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, WV 26506-6106, USA.
出版信息
Nanoscale. 2015 Jul 7;7(25):11005-12. doi: 10.1039/c5nr02142a. Epub 2015 May 26.
Abstract
A surface-enhanced Raman scattering (SERS) biosensor has been developed by incorporating a gold nanohole array with a SERS probe (a gold nanostar@Raman-reporter@silica sandwich structure) into a single detection platform via DNA hybridization, which circumvents the nanoparticle aggregation and the inefficient Raman scattering issues. Strong plasmonic coupling between the Au nanostar and the Au nanohole array results in a large enhancement of the electromagnetic field, leading to amplification of the SERS signal. The SERS sensor has been used to detect Ag(I) and Hg(II) ions in human saliva because both the metal ions could be released from dental amalgam fillings. The developed SERS sensor can be adapted as a general detection platform for non-invasive measurements of a wide range of analytes such as metal ions, small molecules, DNA and proteins in body fluids.
摘要
通过DNA杂交将带有表面增强拉曼散射（SERS）探针（金纳米星@拉曼报告分子@二氧化硅三明治结构）的金纳米孔阵列整合到单个检测平台中，开发出了一种SERS生物传感器，该传感器规避了纳米颗粒聚集和拉曼散射效率低下的问题。金纳米星与金纳米孔阵列之间强烈的等离子体耦合导致电磁场大幅增强，从而使SERS信号得到放大。该SERS传感器已用于检测人唾液中的Ag(I)和Hg(II)离子，因为这两种金属离子都可能从汞合金填充物中释放出来。所开发的SERS传感器可作为一种通用检测平台，用于对体液中的多种分析物（如金属离子、小分子、DNA和蛋白质）进行非侵入式测量。
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