Jefferson Barracks Division, Geriatric Research Education and Clinical Center, Veterans Affairs Saint Louis Health System, Saint Louis, Missouri; Division of Geriatric Medicine, Department of Internal Medicine, School of Medicine, Saint Louis University, Saint Louis, Missouri.
J Am Geriatr Soc. 2014 Jul;62(7):1341-6. doi: 10.1111/jgs.12874. Epub 2014 Jun 10.
To compare the ability of the Veterans Affairs Saint Louis University Mental Status (SLUMS) examination to detect mild cognitive impairment (MCI) and dementia according to the Clinical Dementia Rating Scale (CDR) with that of two other well-known screening instruments, the Montreal Cognitive Assessment (MoCA) and the Short Test of Mental Status (STMS).
Cross-sectional validation study.
Saint Louis Veterans Affairs Medical Center Geriatric Research Education and Clinical Center.
Veterans aged 60 and older (median 78.5) with a high school education or more (n = 136).
Participants were administered the SLUMS examination, the MoCA, and the STMS in random order. A blinded test administrator administered the CDR in a separate session. Receiver operating characteristic (ROC) curves were used to assess the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the SLUMS examination, the MoCA, and the STMS for MCI, dementia, and MCI or dementia. ROC contrasts were used to statistically compare the area under the ROC curve (AUC) for the screening tests' ability to detect cognitive dysfunction according to the CDR.
ROC contrasts demonstrated that the AUCs for detecting MCI (SLUMS examination 0.74, MoCA 0.77, STMS 0.77), dementia (SLUMS examination 0.98, MoCA 0.96, STMS 0.97), and MCI or dementia (SLUMS examination 0.82, MoCA 0.83, STMS 0.84) were equivalent. Sensitivity, specificity, PPV, and NPV were similar across measures of MCI, dementia, and MCI or dementia according to the CDR.
The SLUMS examination has validity similar to that of the MoCA and STMS for the detection of MCI, dementia, and MCI or dementia according to the CDR.
根据临床痴呆评定量表（CDR），比较退伍军人事务部圣路易斯大学精神状态（SLUMS）检查、蒙特利尔认知评估（MoCA）和简易精神状态检查（STMS）这三种常用筛查工具检测轻度认知障碍（MCI）和痴呆的能力。
横断面验证研究。
圣路易斯退伍军人事务医疗中心老年病学研究教育和临床中心。
接受检查者为年龄在 60 岁及以上（中位数 78.5 岁）、受过高中及以上教育的退伍军人（n=136）。
参与者以随机顺序接受 SLUMS 检查、MoCA 和 STMS 检查。一名经过培训的测试管理员在单独的会议中对 CDR 进行了测试。采用受试者工作特征（ROC）曲线评估 SLUMS 检查、MoCA 和 STMS 检测 MCI、痴呆和 MCI 或痴呆的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）。ROC 对比用于统计比较筛查试验根据 CDR 检测认知功能障碍的能力的 ROC 曲线下面积（AUC）。
ROC 对比显示，检测 MCI 的 AUC（SLUMS 检查 0.74、MoCA 0.77、STMS 0.77）、痴呆（SLUMS 检查 0.98、MoCA 0.96、STMS 0.97）和 MCI 或痴呆（SLUMS 检查 0.82、MoCA 0.83、STMS 0.84）的 AUC 相当。根据 CDR，SLUMS 检查、MoCA 和 STMS 对 MCI、痴呆和 MCI 或痴呆的敏感性、特异性、PPV 和 NPV 相似。
根据 CDR，SLUMS 检查与 MoCA 和 STMS 检测 MCI、痴呆和 MCI 或痴呆的能力具有相似的有效性。
