Children's Nutrition Research Centre, Queensland Children's Medical Research Institute, The University of Queensland, Royal Children's Hospital, Herston, QLD, Australia; Centre for Integrative Clinical and Molecular Medicine, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD, Australia; School of Medicine, The University of Queensland, Herston, QLD, Australia.
The School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia.
Nutr Res. 2014 May;34(5):375-82. doi: 10.1016/j.nutres.2014.04.001. Epub 2014 Apr 12.
Dysregulation of adipose hormones in obesity has been associated with the hastened development of metabolic syndrome and associated chronic disease sequalae including cardiovascular disease and type 2 diabetes mellitus. This study aims to identify common biochemical and anthropometric markers that impact adipose hormones, including adiponectin and leptin. Based on previous literature, it was hypothesized that these would be adversely impacted by liver function parameters, and adiponectin levels would be positively correlated with phospholipid Ω-3 fatty acids. Forty nondiabetic adult subjects (body mass index, ≥ 25.0 kg/m(2)) were recruited. Fasting plasma samples were taken to assess adipokine levels, glucose metabolism, electrolytes, liver enzymes, and blood lipids. Basic anthropometric measurements were also recorded. Adiponectin levels were positively correlated with high-density lipoprotein cholesterol and negatively correlated with anthropometric measures, insulin, liver enzymes, triglycerides, and very low-density lipoprotein cholesterol but not body mass index. Conversely, plasma leptin levels were positively correlated with anthropometric measures, C-reactive protein, high-density lipoprotein cholesterol, and plasma phospholipid proportions of Ω-3 α linoleic acid but inversely correlated with creatinine levels. These results support other data regarding correlations between adiponectin and relative adipose distribution. Correlations with specific liver enzymes may indicate that adiponectin levels are tied to fatty acid deposition in the liver; however, liver/kidney damage though further mechanistic clarification is required. Leptin levels were associated with measures of adiposity but not liver enzymes. Each of these variables, along with blood lipids, may serve as potential future therapeutic targets for the prevention and management of obesity and related comorbidities.
肥胖症中脂肪激素的失调与代谢综合征的加速发展以及相关的慢性疾病后果（包括心血管疾病和 2 型糖尿病）有关。本研究旨在确定影响脂肪激素（包括脂联素和瘦素）的常见生化和人体测量学指标。根据以往的文献，我们假设这些指标会受到肝功能参数的不利影响，并且脂联素水平与磷脂 ω-3 脂肪酸呈正相关。本研究招募了 40 名非糖尿病成年受试者（体重指数≥25.0kg/m²）。采集空腹血浆样本以评估脂肪激素水平、葡萄糖代谢、电解质、肝功能酶和血脂。还记录了基本的人体测量学指标。脂联素水平与高密度脂蛋白胆固醇呈正相关，与人体测量学指标、胰岛素、肝功能酶、甘油三酯和极低密度脂蛋白胆固醇呈负相关，但与体重指数无关。相反，血浆瘦素水平与人体测量学指标、C 反应蛋白、高密度脂蛋白胆固醇和血浆磷脂 ω-3 α-亚麻酸比例呈正相关，但与肌酐水平呈负相关。这些结果支持其他关于脂联素与相对脂肪分布之间相关性的研究数据。与特定的肝功能酶的相关性可能表明脂联素水平与肝脏中脂肪酸的沉积有关；然而，还需要进一步的机制阐明来了解肝脏/肾脏损伤。瘦素水平与肥胖程度的指标有关，但与肝功能酶无关。这些变量中的每一个，以及血脂，都可能成为预防和管理肥胖症及其相关并发症的潜在未来治疗靶点。
