Department of Respiratory Medicine, Royal Children's Hospital, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia.
Department of Respiratory Medicine, Royal Children's Hospital, Melbourne, Australia.
J Cyst Fibros. 2014 Dec;13(6):687-91. doi: 10.1016/j.jcf.2014.05.012. Epub 2014 Jun 7.
There is currently limited information regarding lung clearance index (LCI) and its response to treatment of pulmonary exacerbations in CF. We aimed to examine the utility of LCI for assessing short term clinical response to IV antibiotic therapy in school-age children with CF.
Subjects experiencing exacerbations and hospitalised for IV antibiotics performed both multiple breath nitrogen washout (MBNW) and spirometry on admission to hospital and prior to discharge.
27 patients (aged 6-20 years) had paired data for MBNW and spirometry. Mean LCI reduced from 12.18 to 11.65 (4.4%) by time of discharge and FEV1z-score improved from -3.05 to -2.86 (6.2%). Overall, LCI improved in n=15 (55%) patients compared with n=18 (67%) where FEV1 improved.
In summary, these findings do not support the use of LCI (or indeed, FEV1) to gauge the short term clinical response to IV antibiotic therapy in school-age children with cystic fibrosis.
目前关于肺清除指数（LCI）及其对 CF 肺部恶化治疗反应的信息有限。我们旨在研究 LCI 在评估 CF 学龄儿童静脉抗生素治疗短期临床反应中的效用。
患有恶化且需要静脉注射抗生素住院的患者在入院时和出院前进行多次呼吸氮冲洗（MBNW）和肺活量测定。
27 名（年龄 6-20 岁）患者有 MBNW 和肺活量测定的配对数据。出院时 LCI 均值从 12.18 降至 11.65（4.4%），FEV1z 评分从-3.05 提高至-2.86（6.2%）。总体而言，与 FEV1 改善的 18 例（67%）相比，LCI 改善的有 15 例（55%）患者。
综上所述，这些发现不支持使用 LCI（或 FEV1）来评估 CF 学龄儿童静脉抗生素治疗的短期临床反应。
