低强度跑步运动可增加2型糖尿病大鼠比目鱼肌的毛细血管容量和促血管生成因子。
Low-intensity running exercise enhances the capillary volume and pro-angiogenic factors in the soleus muscle of type 2 diabetic rats.
作者信息
Kondo Hiroyo, Fujino Hidemi, Murakami Shinichiro, Tanaka Masayuki, Kanazashi Miho, Nagatomo Fumiko, Ishihara Akihiko, Roy Roland R
机构信息
Department of Food Science and Nutrition, Nagoya Women's University, Nagoya, Japan.
出版信息
Muscle Nerve. 2015 Mar;51(3):391-9. doi: 10.1002/mus.24316. Epub 2015 Jan 6.
INTRODUCTION
We determined the effects of low-intensity exercise on the three-dimensional capillary structure and associated angiogenic factors in the soleus muscle of Goto-Kakizaki (GK) diabetic rats.
METHODS
Four groups of male rats were studied: sedentary nondiabetic (Con), exercised nondiabetic control (Ex), sedentary GK, and exercised GK (GK+Ex). Rats in the Ex and GK+Ex groups were subjected to chronic low-intensity running on a treadmill (15 m/min, 60 min/session, 5 sessions/week for 3 weeks).
RESULTS
Although mean capillary volume and diameter were lower in the GK compared with all other groups, low-intensity exercise increased both of these measures in GK rats. Mitochondrial markers, i.e., SDH activity and PGC-1α expression, and the levels of angiogenic factors were higher in the GK+Ex than all other groups. Exercise increased vascular endothelial growth factor (VEGF) protein levels and the VEGF-to-TSP-1 ratio, an indicator of angiogenesis, in GK rats.
CONCLUSIONS
Combined, the results indicate that low-intensity exercise reduces some of the microcirculatory complications in type 2 diabetic muscles.
引言
我们确定了低强度运动对五岛 - 梶崎（GK）糖尿病大鼠比目鱼肌三维毛细血管结构及相关血管生成因子的影响。
方法
研究了四组雄性大鼠：久坐不动的非糖尿病组（Con）、运动的非糖尿病对照组（Ex）、久坐不动的GK组和运动的GK组（GK + Ex）。Ex组和GK + Ex组的大鼠在跑步机上进行慢性低强度跑步（15米/分钟，每次60分钟，每周5次，共3周）。
结果
尽管GK组的平均毛细血管体积和直径低于所有其他组，但低强度运动使GK大鼠的这两项指标均有所增加。GK + Ex组的线粒体标志物，即琥珀酸脱氢酶（SDH）活性和过氧化物酶体增殖物激活受体γ共激活因子1α（PGC - 1α）表达以及血管生成因子水平均高于所有其他组。运动增加了GK大鼠血管内皮生长因子（VEGF）蛋白水平以及血管生成指标VEGF与血小板反应蛋白1（TSP - 1）的比值。
结论
综合来看，结果表明低强度运动可减轻2型糖尿病肌肉中的一些微循环并发症。
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