特应性皮炎患者的癫痫风险：一项全国性纵向研究。

Risk of epilepsy among patients with atopic dermatitis: a nationwide longitudinal study.

作者信息

Chen Mu-Hong, Wu Yi-Hui, Su Tung-Ping, Chen Ying-Sheue, Hsu Ju-Wei, Huang Kai-Lin, Li Cheng-Ta, Lin Wei-Chen, Chang Wen-Han, Chen Tzeng-Ji, Bai Ya-Mei

机构信息

Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan.

出版信息

Epilepsia. 2014 Aug;55(8):1307-12. doi: 10.1111/epi.12667. Epub 2014 Jun 10.

DOI:10.1111/epi.12667

PMID:24917387

Abstract

OBJECTIVE

Both atopic dermatitis and epilepsy have been regarded as chronic inflammatory diseases. However, their association has yet to be investigated.

METHODS

Using the Taiwan National Health Insurance Research Database, 35,312 patients with atopic dermatitis but without a history of epilepsy, and 35,312 age-/gender-matched controls were enrolled between 1998 and 2008, and followed to the end of 2011 to identify the development of epilepsy.

RESULTS

Subjects with atopic dermatitis had a higher incidence of developing epilepsy (0.94 vs. 0.27/1,000 person-years, p < 0.001) than the control group. The Cox regression model showed that atopic dermatitis increased the risk of developing epilepsy (hazard ratio [HR] 2.91, 95% confidence interval [CI] 2.23-3.82) after adjusting for demographic data and medical comorbidities. Sensitivity tests showed consistent findings (HR 2.32, 95% CI 1.68-2.96) after excluding the first year of observation. In addition, asthma (HR 1.34, 95% CI 1.04-1.72) and allergic rhinitis (HR 1.34, 95% CI 1.04-1.73) were related to the risk of epilepsy.

SIGNIFICANCE

Subjects with atopic dermatitis were associated with an increased risk of developing epilepsy in later life. Further studies would be needed to investigate the underlying mechanisms.

摘要

目的

特应性皮炎和癫痫均被视为慢性炎症性疾病。然而，它们之间的关联尚未得到研究。

方法

利用台湾国民健康保险研究数据库，纳入了35312例无癫痫病史的特应性皮炎患者以及35312例年龄和性别匹配的对照，研究时间段为1998年至2008年，并随访至2011年底以确定癫痫的发生情况。

结果

特应性皮炎患者发生癫痫的发生率高于对照组（0.94对0.27/1000人年，p<0.001）。Cox回归模型显示，在调整人口统计学数据和合并症后，特应性皮炎增加了发生癫痫的风险（风险比[HR]2.91，95%置信区间[CI]2.23 - 3.82）。敏感性测试显示，在排除观察的第一年之后，结果一致（HR 2.32，95% CI 1.68 - 2.96）。此外，哮喘（HR 1.34，95% CI 1.04 - 1.72）和过敏性鼻炎（HR 1.34，95% CI 1.04 - 1.73）与癫痫风险相关。