Jonsson L, Alm G, Thomander L
Department of Otolaryngology, Akademiska Sjukhuset, Uppsala University, Sweden.
Arch Otolaryngol Head Neck Surg. 1989 Jan;115(1):37-40. doi: 10.1001/archotol.1989.01860250039022.
Serum interferon (IFN) levels were analyzed in patients with Bell's palsy to study the immune response in the disease. Serum samples from 91 patients were assayed for antiviral activity using a bioassay. The IFN levels in the serum were elevated in the acute and convalescent phases as compared with control subjects. The serum IFN-gamma levels were analyzed by radioimmunoassay in 32 of the patients: the IFN-gamma levels were alike in the acute and convalescent phases and the control subjects. Neutralization with specific antisera against IFN-alpha, -beta, and -gamma on 15 serum samples of 11 patients with elevated IFN activity showed a complex pattern that indicates that the antiviral activity was due to a mixture of IFNs and possibly also due to other factors. The elevated IFN levels indicate a low-grade antiviral response that may reflect the reactivation of a viral infection.
分析贝尔氏面瘫患者的血清干扰素（IFN）水平，以研究该疾病中的免疫反应。使用生物测定法对91例患者的血清样本进行抗病毒活性检测。与对照受试者相比，急性和恢复期患者血清中的IFN水平升高。对32例患者采用放射免疫分析法分析血清干扰素-γ水平：急性和恢复期患者以及对照受试者的干扰素-γ水平相似。对11例IFN活性升高患者的15份血清样本用抗干扰素-α、-β和-γ的特异性抗血清进行中和试验，结果显示出复杂的模式，表明抗病毒活性是由于多种干扰素混合所致，也可能还归因于其他因素。IFN水平升高表明存在低度抗病毒反应，这可能反映了病毒感染的再激活。
