Hughes G B, Barna B P, Kinney S E, Goren H, Sweeney P J, Valenzuela R, Calabrese L H, Tucker H M
Otolaryngol Head Neck Surg. 1986 Dec;95(5):586-8. doi: 10.1177/019459988609500511.
Although the pathogenesis of acute facial (Bell's) palsy is probably multifactorial, some investigators believe that the disorder results from autoimmune demyelination and is perhaps related to previous viral infection. The purpose of this study was to identify immune mechanisms which might contribute to Bell's palsy. The lymphocyte transformation test and immunofluorescence were evaluated with a soluble homogenate of unrefined peripheral nerve antigens. Three antigen-nonspecific tests were also studied. Results in 14 patients with Bell's palsy were compared with those in 21 controls. To be eligible for study, patients with Bell's palsy had to be seen within 10 days of onset of weakness. The control group included 5 patients with facial nerve dysfunction from other causes and 16 normal volunteers. No patient or control had previously received steroids. Five patients with Bell's palsy and one normal volunteer had abnormal lymphocyte transformation (p less than .05). Virtually all other tests were normal. These results. suggest that some instances of Bell's palsy result from cell-mediated immunity against peripheral nerve antigens. They also encourage further research in steroid and other immunotherapy.
尽管急性面瘫（贝尔氏面瘫）的发病机制可能是多因素的，但一些研究者认为该疾病是由自身免疫性脱髓鞘引起的，可能与既往病毒感染有关。本研究的目的是确定可能导致贝尔氏面瘫的免疫机制。采用未提纯的周围神经抗原可溶性匀浆对淋巴细胞转化试验和免疫荧光进行评估。还研究了三项抗原非特异性试验。将14例贝尔氏面瘫患者的结果与21例对照者的结果进行比较。为符合研究条件，贝尔氏面瘫患者必须在出现肌无力症状的10天内就诊。对照组包括5例由其他原因导致面神经功能障碍的患者和16名正常志愿者。所有患者和对照者此前均未接受过类固醇治疗。5例贝尔氏面瘫患者和1名正常志愿者的淋巴细胞转化试验结果异常（p<0.05）。几乎所有其他试验结果均正常。这些结果表明，某些贝尔氏面瘫病例是由针对周围神经抗原的细胞介导免疫引起的。它们还鼓励对类固醇及其他免疫疗法进行进一步研究。
