Ege University School of Medicine, Sect Gastroenterology & Ege Reflux Study Group, Izmir, Turkey.
Karsiyaka Manucipality Hospital, Gastroenterology, Izmir, Turkey.
United European Gastroenterol J. 2013 Oct;1(5):346-50. doi: 10.1177/2050640613500266.
There is a general belief that gastro-oesophageal reflux increases after meals and especially following a rapid intake.
To evaluate the impact of rapid vs. slow food intake on gastro-oesophageal reflux disease (GORD) patients.
Forty-six GORD patients with heartburn and / or acid regurgitation once a week or more often common were included in this study. Participants were asked to eat the same standard meal within either 5 or 30 minutes under observation in a random order on 2 consecutive days. A total of 28 hours of recording were obtained by intraoesophageal impedance pH and number of liquid and mixed reflux episodes within 3 hours of the slow- and fast-eating postprandial periods were calculated.
While all patients defined GORD symptoms, 10 (21.7%) had pathological 24-h intraoesophageal impedance measurement, 15 (32.6%) had pathological DeMeester and 21.7% had erosive oesophagitis. No difference has been shown according to the eating speed when all reflux episodes were taken together (754 vs. 733). Speed of food intake also did not have an impact on patients with normal vs. pathological 24-h intraoesophageal impedance or erosive vs. non-erosive. During the first postprandial hour, approximately half of the reflux events were non-acid, compared to 34.2% during the second hour and 26.8% during the third hour (p < 0.001). The number of acid reflux episodes was significantly higher than non-acid reflux especially during the second and third hours and in total for 3 hours.
This first study addressing the effect of eating speed on reflux episodes in GORD patients did not support the general belief that reflux increases following fast eating. Acid and non-acid reflux were similar at the first postprandial hour, then acid reflux episodes were predominantly higher, which implicate the importance of acid pockets.
人们普遍认为，胃食管反流在餐后会增加，尤其是在快速进食后。
评估快速进食与缓慢进食对胃食管反流病（GORD）患者的影响。
本研究纳入了 46 例每周有一次或多次烧心和/或胃酸反流的 GORD 患者。参与者被要求在连续两天内以随机顺序在 5 分钟或 30 分钟内吃完相同的标准餐。通过食管内阻抗 pH 记录获得总共 28 小时的记录，并计算出慢食和快食餐后 3 小时内液体和混合反流次数。
虽然所有患者均定义为 GORD 症状，但 10 例（21.7%）24 小时食管内阻抗测量结果异常，15 例（32.6%）DeMeester 测试结果异常，21.7%有糜烂性食管炎。当所有反流事件一起考虑时，进食速度没有差异（754 次对 733 次）。进食速度也没有影响正常与异常 24 小时食管内阻抗或糜烂与非糜烂患者。在第一餐后小时，大约一半的反流事件是非酸性的，而在第二小时和第三小时分别为 34.2%和 26.8%（p<0.001）。酸反流次数明显高于非酸反流，尤其是在第二和第三小时以及 3 小时总反流次数中。
这是第一项研究进食速度对 GORD 患者反流事件影响的研究，该研究不支持快速进食后反流增加的普遍观点。在第一餐后小时，酸反流和非酸反流相似，然后酸反流事件明显增多，这表明酸口袋的重要性。
