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O-连接的N-乙酰葡糖胺糖基化修饰:癌症的甜蜜一面

O-GlcNAcylation: The Sweet Side of the Cancer.

作者信息

de Queiroz Rafaela Muniz, Carvalho Erika, Dias Wagner Barbosa

机构信息

Laboratório de Glicobiologia Estrutural e Funcional, Centro de Ciências da Saúde - Bloco G, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Instituto de Bioquimica Médica, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

出版信息

Front Oncol. 2014 Jun 3;4:132. doi: 10.3389/fonc.2014.00132. eCollection 2014.

Abstract

O-GlcNAcylation is an O-linked β-N-acetylglucosamine (O-GlcNAc) moiety linked to the serine or threonine residues in proteins. O-GlcNAcylation is a dynamic post-translational modification involved in a wide range of biological processes and diseases such as cancer. This modification can increase and decrease the activity of enzymes as well as interfere with protein stability and interaction. The modulatory capacity of O-GlcNAcylation, as well as protein phosphorylation, is of paramount importance in the regulation of metabolism and intracellular signaling of tumor cells. Thus, understanding the regulation of O-GlcNAcylation in tumor cells and their difference compared to non-tumor cells may elucidate new mechanisms related to tumor generation and development, could provide a new marker to diagnosis and prognosis in patients with cancer and indicate a new target to cancer chemotherapy.

摘要

O-连接的N-乙酰葡糖胺化是一种与蛋白质中的丝氨酸或苏氨酸残基相连的O-连接β-N-乙酰葡糖胺(O-GlcNAc)部分。O-连接的N-乙酰葡糖胺化是一种动态的翻译后修饰,参与广泛的生物过程和疾病,如癌症。这种修饰可以增加和降低酶的活性,以及干扰蛋白质的稳定性和相互作用。O-连接的N-乙酰葡糖胺化以及蛋白质磷酸化的调节能力在肿瘤细胞的代谢和细胞内信号传导调节中至关重要。因此,了解肿瘤细胞中O-连接的N-乙酰葡糖胺化的调节及其与非肿瘤细胞的差异,可能阐明与肿瘤发生和发展相关的新机制,可为癌症患者的诊断和预后提供新的标志物,并为癌症化疗指明新的靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e918/4042083/d7251798852d/fonc-04-00132-g001.jpg

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