Jacobs A J, Dawoud L, Kovacs Z, Ratliff T L
Department of Obstetrics and Gynecology, St. Louis University School of Medicine, Missouri 63104.
Gynecol Oncol. 1989 Jan;32(1):31-6. doi: 10.1016/0090-8258(89)90845-7.
The authors studied the effects of recombinant interferons (IFN), doxorubicin, and cisplatin against three cell lines derived from human epidermoid cervical carcinomas. These lines were SW 756, containing the genome of human papillomavirus (HPV) type 18, and CaSki and SiHa, containing HPV type 16. IFN-gamma suppressed the growth of all three lines, with a plateau in inhibitory effect beyond a concentration of 1000 units/ml. IFN-alpha was effective in this regard only against SW 756. In this line, the two IFNs together inhibited cell replication to a greater extent than the maximal effect of either IFN alone. Doxorubicin exerted a dose-dependent cytotoxic effect against all the lines, while cisplatin exhibited cytotoxicity only against SW 756. Doxorubicin and IFN-gamma, when used together, acted synergistically against CaSki and SiHa, and in an additive manner against SW 756.
作者研究了重组干扰素（IFN）、阿霉素和顺铂对三种源自人宫颈表皮样癌的细胞系的作用。这些细胞系分别是含有18型人乳头瘤病毒（HPV）基因组的SW 756，以及含有16型HPV的CaSki和SiHa。γ干扰素抑制了所有三种细胞系的生长，在浓度超过1000单位/毫升时抑制作用达到平台期。α干扰素仅对SW 756在这方面有效。在该细胞系中，两种干扰素共同作用比单独使用任何一种干扰素的最大作用更能抑制细胞复制。阿霉素对所有细胞系均产生剂量依赖性细胞毒性作用，而顺铂仅对SW 756表现出细胞毒性。阿霉素和γ干扰素联合使用时，对CaSki和SiHa起协同作用，对SW 756起相加作用。
