Burris Katy, Ding Catherine Y, Lim Geoffrey F S
J Drugs Dermatol. 2014 Jun;13(6):755-7.
Leuprolide acetate, a gonadotropin-releasing hormone agonist, is used in the treatment of prostate cancer. We report a unique case of a disseminated papular rash following leuprolide acetate injections in a 65-year-old man that shares clinical and histopathological features of papuloerythroderma of Ofuji. Leuprolide-induced papuloerythroderma, as well as a limited number of other disseminated cutaneous eruptions caused by this drug, is extremely rare, with only one case previously reported. Our case calls attention to this uncommon side effect in a commonly used hormonal therapy.
醋酸亮丙瑞林是一种促性腺激素释放激素激动剂，用于治疗前列腺癌。我们报告了一例65岁男性在注射醋酸亮丙瑞林后出现播散性丘疹性皮疹的独特病例，该病例具有Ofuji红皮病性丘疹的临床和组织病理学特征。亮丙瑞林诱发的红皮病性丘疹，以及由该药物引起的其他少数播散性皮肤疹极为罕见，此前仅报道过一例。我们的病例提醒人们注意这种常用激素疗法中不常见的副作用。
