Medeiros Lucas Pereira Jorge de, Kayo Monica, Medeiros Renata Barboza Vianna, Lima Mario Barreto Correa, Mello Carlos Eduardo Brandão Mello
Federal University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
University of São Paulo, School of Medicine, São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992). 2014 Jan-Feb;60(1):35-9. doi: 10.1590/1806-9282.60.01.009.
To assess the incidence rate and severity of depressive symptoms in different time points (12, 24 and 48 weeks) in Brazilian patients with HCV treated with PEG IFN plus ribavirin.
We conducted an observational prospective study using the Beck Depression Inventory (BDI) and the Center for Epidemiologic Studies Depression Scale (CES-D).
Fifty patients were included. The assessments with either scale showed the highest score of depressive symptoms in the 24(th) week of treatment; the mean BDI score before treatment was 6.5 ± 5.3 and the mean CES-D was 10.9 ± 7.8. After 24 weeks, the mean BDI was 16.1 ± 10.2 and mean CES-D was 18.6 ± 13.0; 46% were diagnosed with depression according to combined BDI and CES-D scores. The somatic/psychomotor subscales were highly correlated with overall scale scores . Subjects with history of substance and alcohol abuse had higher risk for IFN-induced depression.
Treatment with PEG IFN was associated with a high incidence rate of depressive symptoms in this sample of Brazilian patients, as measured by CES-D and BDI. Alcohol and substance abuse increase the risk of PEG IFN-induced depression.
评估聚乙二醇干扰素联合利巴韦林治疗的巴西丙型肝炎病毒（HCV）患者在不同时间点（12周、24周和48周）抑郁症状的发生率及严重程度。
我们使用贝克抑郁量表（BDI）和流行病学研究中心抑郁量表（CES-D）进行了一项前瞻性观察研究。
纳入50例患者。两种量表评估均显示治疗第24周时抑郁症状得分最高；治疗前BDI平均得分为6.5±5.3，CES-D平均得分为10.9±7.8。24周后，BDI平均得分为16.1±10.2，CES-D平均得分为18.6±13.0；根据BDI和CES-D综合得分，46%的患者被诊断为抑郁。躯体/精神运动性子量表与总量表得分高度相关。有药物和酒精滥用史的受试者发生干扰素诱导性抑郁的风险更高。
通过CES-D和BDI测量，在该巴西患者样本中，聚乙二醇干扰素治疗与抑郁症状的高发生率相关。酒精和药物滥用会增加聚乙二醇干扰素诱导性抑郁的风险。
