Rosenberg N L, Myers J A, Martin W R
Research Service, Veterans Administration Medical Center, Denver, CO 80220.
Neurology. 1989 Jan;39(1):142-4. doi: 10.1212/wnl.39.1.142.
A 46-year-old man ingested 1,500 mg of potassium cyanide in a suicide attempt. He survived, but later developed a severe parkinsonian syndrome. MRI revealed multiple areas of low-signal intensity in the globus pallidus and posterior putamen. A 6-fluorodopa PET study revealed bilateral decreased uptake in the basal ganglia. This evidence of functional impairment of dopaminergic nigrostriatal neurons is related either to direct toxicity of cyanide or to the effects of cerebral hypoxia secondary to cyanide intoxication.
一名46岁男子为自杀吞服了1500毫克氰化钾。他幸存了下来，但后来出现了严重的帕金森综合征。磁共振成像（MRI）显示苍白球和壳核后部有多个低信号区。6-氟多巴正电子发射断层扫描（PET）研究显示双侧基底神经节摄取减少。多巴胺能黑质纹状体神经元功能受损的这一证据与氰化物的直接毒性或氰化物中毒继发的脑缺氧效应有关。
