Mahmoudi Hilda, Jafari Peyman, Ghaffaripour Sina
Shiraz University of Medical Sciences, Shiraz, Iran.
Prog Transplant. 2014 Jun;24(2):126-31. doi: 10.7182/pit2014491.
Health-related quality of life is a preferred outcome measure for patients with advanced liver disease. The functional health status charts developed by the Dartmouth Primary Care Cooperative Information Project (COOP)/World Organization of National Colleges, Academies and Academic Associations (WONCA) make up a generic instrument for assessing health-related quality of life.
To translate and validate the Persian version of COOP/WONCA in liver transplant candidates and to assess the correlation of Child Pugh classification and Model of End Stage Liver Disease (MELD) score with quality of life.Setting-The Shiraz liver transplant center, the most active liver transplant center in the Middle East.
Consecutive adult outpatients waiting for their first liver transplant who attended follow-up visits in the pretransplant clinic.Main Outcome Measures-Patients completed COOP/WONCA along with the Short Form (SF)-36. Data on the underlying cause of cirrhosis, Child-Pugh classification, and MELD scores were collected from medical records.
A Persian version of the COOP/WONCA was accepted by liver transplant candidates and showed adequate reliability and validity. Similar domains in COOP/WONCA charts and the SF-36 were highly correlated, indicating that construct validity of the COOP/WONCA in relation to the SF-36 was good (77% of correlations were as expected). Moreover, the exploratory factor analysis could not extract 2 different quality-of-life factors. These findings provide sufficient evidence to conclude that the Persian versions of COOP/WONCA charts and the SF-36 measure the same constructs of health-related quality of life and can be used interchangeably. Four of the 6 COOP/WONCA charts did not allow discrimination between groups of patients according to Child Pugh classification, indicating poor known group validity.
健康相关生活质量是晚期肝病患者首选的疗效指标。由达特茅斯初级保健合作信息项目（COOP）/世界家庭医生组织（WONCA）制定的功能健康状况图表构成了一种评估健康相关生活质量的通用工具。
翻译并验证COOP/WONCA波斯语版本在肝移植候选者中的有效性，并评估Child-Pugh分级和终末期肝病模型（MELD）评分与生活质量的相关性。地点——设拉子肝移植中心，中东地区最活跃的肝移植中心。
连续的成年门诊患者，他们在移植前门诊接受随访，等待首次肝移植。主要疗效指标——患者完成COOP/WONCA以及简短健康调查问卷（SF-36）。从病历中收集肝硬化的潜在病因、Child-Pugh分级和MELD评分的数据。
肝移植候选者接受了COOP/WONCA的波斯语版本，该版本显示出足够的信度和效度。COOP/WONCA图表和SF-36中的相似领域高度相关，表明COOP/WONCA相对于SF-36的结构效度良好（77%的相关性符合预期）。此外，探索性因素分析未能提取出两种不同的生活质量因素。这些发现提供了充分的证据，可以得出结论：COOP/WONCA图表的波斯语版本和SF-36测量的是健康相关生活质量的相同结构，并且可以互换使用。6个COOP/WONCA图表中的4个无法根据Child-Pugh分级区分患者组，表明已知组效度较差。
