Berry A, Campsen J, Shihab F, Firszt R
Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Clin Exp Allergy. 2014 Aug;44(8):1020-2. doi: 10.1111/cea.12355.
The transfer of peanut allergy has been reported following solid organ transplantation.
Present a case of peanut sensitization following combined pancreas-and-kidney transplantation.
Circulating specific IgE against peanut were measured in serum samples collected from the transplant recipient 1 month before transplantation, and 1, 3 and 6 months after transplantation. Skin tests were performed 1, 3 and 6 months following transplant.
The organ recipient's pre-transplant peanut IgE levels were negative. At 1 month post-transplant, the patient had a 6 mm skin test to peanut and had serum IgE to peanut Arah1 of 0.79 kU/L. At 3 months, skin test size and IgE to peanut Arah1 decreased to 4 mm, and 0.69 kU/L respectively. At 6 months, the patient's skin test and IgE to peanuts were negative. At that time, the patient underwent a peanut food challenge without a clinical reaction to suggest allergy.
We report the development of IgE peanut sensitization in a recipient of a combined pancreas and kidney transplantation. Increasing awareness of this allergen sensitization following transplantation may help prevent serious allergic reactions in transplant recipients.
实体器官移植后已报道有花生过敏的转移情况。
呈现一例胰肾联合移植后花生致敏的病例。
在移植前1个月以及移植后1、3和6个月采集移植受者的血清样本，检测其中针对花生的循环特异性IgE。在移植后1、3和6个月进行皮肤试验。
器官受者移植前花生IgE水平为阴性。移植后1个月，患者对花生的皮肤试验为6毫米，血清中花生Ara h1的IgE为0.79 kU/L。3个月时，对花生的皮肤试验大小和花生Ara h1的IgE分别降至4毫米和0.69 kU/L。6个月时，患者对花生的皮肤试验和IgE均为阴性。此时，患者接受了花生食物激发试验，未出现提示过敏的临床反应。
我们报告了一例胰肾联合移植受者中IgE介导的花生致敏情况。提高对移植后这种过敏原致敏的认识可能有助于预防移植受者发生严重过敏反应。
