内分泌学与青春期：有氧运动可降低肥胖青少年的胰岛素抵抗标志物：一项随机对照试验的荟萃分析。
Endocrinology and Adolescence: aerobic exercise reduces insulin resistance markers in obese youth: a meta-analysis of randomized controlled trials.
机构信息
Facultad de Ciencias de la SaludUniversidad Autónoma de Chile, Talca, ChileAFIDES Research GroupFacultad de Ciencias del Deporte, Universidad de Extremadura, Cáceres, SpainSocial and Health Care Research CenterUniversity of Castilla-La Mancha, Edificio Melchor Cano, Centro de Estudios Socio-Sanitarios, Santa Teresa Jornet s/n, 16071 Cuenca, SpainSchool of EducationUniversity of Castilla-La Mancha, Ciudad Real, Spain.
Facultad de Ciencias de la SaludUniversidad Autónoma de Chile, Talca, ChileAFIDES Research GroupFacultad de Ciencias del Deporte, Universidad de Extremadura, Cáceres, SpainSocial and Health Care Research CenterUniversity of Castilla-La Mancha, Edificio Melchor Cano, Centro de Estudios Socio-Sanitarios, Santa Teresa Jornet s/n, 16071 Cuenca, SpainSchool of EducationUniversity of Castilla-La Mancha, Ciudad Real, Spain Facultad de Ciencias de la SaludUniversidad Autónoma de Chile, Talca, ChileAFIDES Research GroupFacultad de Ciencias del Deporte, Universidad de Extremadura, Cáceres, SpainSocial and Health Care Research CenterUniversity of Castilla-La Mancha, Edificio Melchor Cano, Centro de Estudios Socio-Sanitarios, Santa Teresa Jornet s/n, 16071 Cuenca, SpainSchool of EducationUniversity of Castilla-La Mancha, Ciudad Real, Spain.
出版信息
Eur J Endocrinol. 2014 Oct;171(4):R163-71. doi: 10.1530/EJE-14-0291. Epub 2014 Jun 11.
OBJECTIVE
The purpose of this meta-analysis was to examine the evidence for the effectiveness of aerobic exercise interventions on reducing insulin resistance markers in obese children and/or adolescents. A secondary outcome was change in percentage of body fat.
METHODS
A computerized search was made from seven databases: CINAHL, Cochrane Central Register of Controlled Trials, EMBASE, ERIC, MEDLINE, PsycINFO, and Science Citation Index. The analysis was restricted to randomized controlled trials that examined the effect of aerobic exercise on insulin resistance markers in obese youth. Two independent reviewers screened studies and extracted data. Effect sizes (ES) and 95% confidence interval (CI) were calculated, and the heterogeneity of the studies was estimated using Cochran's Q-statistic.
RESULTS
Nine studies were selected for meta-analysis as they fulfilled the inclusion criteria (n=367). Aerobic exercise interventions resulted in decreases in fasting glucose (ES=-0.39; low heterogeneity) and insulin (ES=-0.40; low heterogeneity) and in percentage of body fat (ES=-0.35; low heterogeneity). These improvements were specifically accentuated in adolescents (only in fasting insulin), or through programs lasting more than 12 weeks, three sessions per week, and over 60 min of aerobic exercise per session.
CONCLUSIONS
This meta-analysis provides insights into the effectiveness of aerobic exercise interventions on insulin resistance markers in the obese youth population.
目的
本荟萃分析旨在检验有氧运动干预对肥胖儿童和/或青少年降低胰岛素抵抗标志物的有效性证据。次要结果是体脂百分比的变化。
方法
计算机检索了七个数据库：CINAHL、Cochrane 对照试验中心注册库、EMBASE、ERIC、MEDLINE、PsycINFO 和科学引文索引。分析仅限于随机对照试验，这些试验研究了有氧运动对肥胖青少年胰岛素抵抗标志物的影响。两名独立评审员筛选研究并提取数据。计算了效应大小（ES）和 95%置信区间（CI），并使用 Cochran's Q 统计量估计了研究的异质性。
结果
有 9 项研究符合纳入标准（n=367），因此被选择进行荟萃分析。有氧运动干预可降低空腹血糖（ES=-0.39；低异质性）和胰岛素（ES=-0.40；低异质性）以及体脂百分比（ES=-0.35；低异质性）。这些改善在青少年中更为明显（仅在空腹胰岛素方面），或者通过持续时间超过 12 周、每周 3 次、每次有氧运动超过 60 分钟的方案。
结论
本荟萃分析提供了有关有氧运动干预对肥胖青少年人群胰岛素抵抗标志物的有效性的见解。
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