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衰弱预测老年创伤患者结局优于年龄:一项前瞻性分析。

Superiority of frailty over age in predicting outcomes among geriatric trauma patients: a prospective analysis.

机构信息

Division of Trauma, Critical Care, Burns, and Acute Care Surgery, Department of Surgery, University of Arizona Medical Center, Tucson.

出版信息

JAMA Surg. 2014 Aug;149(8):766-72. doi: 10.1001/jamasurg.2014.296.

Abstract

IMPORTANCE

The Frailty Index (FI) is a known predictor of adverse outcomes in geriatric patients. The usefulness of the FI as an outcome measure in geriatric trauma patients is unknown.

OBJECTIVE

To assess the usefulness of the FI as an effective assessment tool in predicting adverse outcomes in geriatric trauma patients.

DESIGN, SETTING, AND PARTICIPANTS: A 2-year (June 2011 to February 2013) prospective cohort study at a level I trauma center at the University of Arizona. We prospectively measured frailty in all geriatric trauma patients. Geriatric patients were defined as those 65 years or older. The FI was calculated using 50 preadmission frailty variables. Frailty in patients was defined by an FI of 0.25 or higher.

MAIN OUTCOMES AND MEASURES

The primary outcome measure was in-hospital complications. The secondary outcome measure was adverse discharge disposition. In-hospital complications were defined as cardiac, pulmonary, infectious, hematologic, renal, and reoperation. Adverse discharge disposition was defined as discharge to a skilled nursing facility or in-hospital mortality. Multivariate logistic regression was used to assess the relationship between the FI and outcomes.

RESULTS

In total, 250 patients were enrolled, with a mean (SD) age of 77.9 (8.1) years, median Injury Severity Score of 15 (range, 9-18), median Glasgow Coma Scale score of 15 (range, 12-15), and mean (SD) FI of 0.21 (0.10). Forty-four percent (n = 110) of patients had frailty. Patients with frailty were more likely to have in-hospital complications (odds ratio, 2.5; 95% CI, 1.5-6.0; P = .001) and adverse discharge disposition (odds ratio, 1.6; 95% CI, 1.1-2.4; P = .001). The mortality rate was 2.0% (n = 5), and all patients who died had frailty.

CONCLUSIONS AND RELEVANCE

The FI is an independent predictor of in-hospital complications and adverse discharge disposition in geriatric trauma patients. This index should be used as a clinical tool for risk stratification in this patient group.

摘要

重要性

衰弱指数(FI)是老年患者不良结局的已知预测因子。FI 作为老年创伤患者结局测量的有效性尚不清楚。

目的

评估 FI 作为一种有效评估工具,预测老年创伤患者不良结局的能力。

设计、地点和参与者:这是一项在亚利桑那大学一级创伤中心进行的为期 2 年(2011 年 6 月至 2013 年 2 月)的前瞻性队列研究。我们前瞻性地测量了所有老年创伤患者的衰弱程度。老年患者定义为 65 岁或以上。FI 通过 50 项入院前衰弱变量计算得出。患者的衰弱程度由 FI 等于或大于 0.25 来定义。

主要结局和测量指标

主要结局指标为院内并发症。次要结局指标为不良出院转归。院内并发症定义为心脏、肺部、感染、血液、肾脏和再次手术。不良出院转归定义为出院至康复护理机构或院内死亡。多变量逻辑回归用于评估 FI 与结局之间的关系。

结果

共有 250 名患者入组,平均(SD)年龄为 77.9(8.1)岁,中位数损伤严重度评分 15(范围 9-18),中位数格拉斯哥昏迷评分 15(范围 12-15),平均(SD)FI 为 0.21(0.10)。44%(n = 110)的患者衰弱。衰弱患者更有可能发生院内并发症(优势比,2.5;95%置信区间,1.5-6.0;P = .001)和不良出院转归(优势比,1.6;95%置信区间,1.1-2.4;P = .001)。死亡率为 2.0%(n = 5),所有死亡患者均衰弱。

结论和相关性

FI 是老年创伤患者院内并发症和不良出院转归的独立预测因子。该指数应作为该患者群体风险分层的临床工具使用。

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