在 CF 患儿中，亚极量运动后心率恢复与极量运动测试之间有何相关性？
How does heart rate recovery after sub-maximal exercise correlate with maximal exercise testing in children with CF?
机构信息
University of Pittsburgh School of Medicine, 5806 Ellsworth Ave #1, Pittsburgh, PA 15232, United States.
Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC, United States.
出版信息
J Cyst Fibros. 2014 Dec;13(6):712-5. doi: 10.1016/j.jcf.2014.05.011. Epub 2014 Jun 8.
BACKGROUND
Disease progression in cystic fibrosis (CF) is marked by worsening exercise tolerance. Further, maximal exercise capacity (VO2 peak) correlates with survival in CF, but maximal tests are uncomfortable and resource-intensive. A three-minute step test (STEP) has been validated in CF. Heart rate (HR) recovery after exercise correlates with all-cause mortality in adult non-CF populations. We compared HR recovery after the three-minute step test with VO2 peak in children with CF.
METHODS
Twenty-four children with CF performed STEP and a maximal exercise test. Correlation between the tests was assessed.
RESULTS
Maximum HR on STEP was lower than on the maximal test (140 vs. 190, p<0.01). Peak HR during STEP correlated inversely with VO2 peak. In subjects with mild lung disease, faster HR recovery after STEP correlated with higher VO2 peak.
CONCLUSIONS
The three-minute step test is a feasible submaximal test in this patient population. HR during and after a three-minute step test may reflect VO2 peak in children with CF.
背景
囊性纤维化（CF）的疾病进展以运动耐量恶化为标志。此外，最大运动能力（VO2 峰值）与 CF 患者的生存率相关，但最大运动测试既不适也耗费资源。三分钟台阶测试（STEP）已在 CF 中得到验证。运动后心率（HR）恢复与非 CF 成人的全因死亡率相关。我们比较了 CF 患儿 STEP 后 HR 恢复与 VO2 峰值的关系。
方法
24 例 CF 患儿进行了 STEP 和最大运动测试。评估了两种测试之间的相关性。
结果
STEP 时的最大 HR 低于最大测试时的 HR（140 比 190，p<0.01）。STEP 期间的峰值 HR 与 VO2 峰值呈负相关。在轻度肺部疾病患者中，STEP 后 HR 恢复较快与 VO2 峰值较高相关。
结论
三分钟台阶测试是该患者人群中可行的亚最大测试。CF 患儿在 STEP 期间和之后的 HR 可能反映 VO2 峰值。
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