Redemption of autoreactive B cells.
作者信息
Haynes Barton F, Verkoczy Laurent, Kelsoe Garnett
机构信息
Departments of Medicine,Immunology, andDuke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710
Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710Pathology, and.
出版信息
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9022-3. doi: 10.1073/pnas.1407877111. Epub 2014 Jun 11.
Abstract
摘要
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本文引用的文献
1
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.通过可变区糖基化和突变远离自身反应性来拯救无能 B 细胞上的自身抗体。
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12.
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AIDS/HIV. Host controls of HIV neutralizing antibodies.艾滋病/艾滋病毒。宿主对 HIV 中和抗体的控制。
Science. 2014 May 9;344(6184):588-9. doi: 10.1126/science.1254990.
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Autoreactivity in HIV-1 broadly neutralizing antibodies: implications for their function and induction by vaccination.HIV-1 广谱中和抗体的自身反应性：对其功能和疫苗诱导的影响。
Curr Opin HIV AIDS. 2014 May;9(3):224-34. doi: 10.1097/COH.0000000000000049.
4
Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus.人类系统性红斑狼疮中 9G4 B 细胞自身反应的分子基础。
J Immunol. 2013 Nov 15;191(10):4926-39. doi: 10.4049/jimmunol.1202263. Epub 2013 Oct 9.
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Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses.2F5 基因敲入小鼠中 HIV-1 广谱中和抗体的诱导：针对膜近端外区相关自身反应性的选择限制了 T 依赖性反应。
J Immunol. 2013 Sep 1;191(5):2538-50. doi: 10.4049/jimmunol.1300971. Epub 2013 Aug 5.
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Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10.常见的耐受机制，但与 gp41 和脂质相关的独特交叉反应性，限制了 HIV-1 广谱中和抗体 2F5 和 4E10 的产生。
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Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.鉴定 2F5 和 4E10 广谱中和抗 HIV-1 抗体所识别的自身抗原。
J Exp Med. 2013 Feb 11;210(2):241-56. doi: 10.1084/jem.20121977. Epub 2013 Jan 28.
8
Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.生发中心来源的自身反应性 B 细胞的消除受自身抗原的位置和浓度控制。
Immunity. 2012 Nov 16;37(5):893-904. doi: 10.1016/j.immuni.2012.07.017. Epub 2012 Nov 8.
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Germinal centers.生发中心。
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