Remorgida V, Venturini P L, Anserini P, Lanera P, De Cecco L
Department of Obstetrics and Gynecology, University of Genoa, Ospedale, San Martino, Italy.
Am J Obstet Gynecol. 1989 Jan;160(1):108-13. doi: 10.1016/0002-9378(89)90099-9.
Nine women with chronic anovulation caused by polycystic ovarian disease, which was unresponsive to clomiphene citrate therapy, were given a gonadotropin-releasing hormone agonist (buserelin) to induce pituitary desensitization. After 4 weeks induction of ovulation was attempted with a step-up administration of urinary follicle-stimulating hormone. Buserelin treatment was discontinued only in the presence of a positive pregnancy test result. Different responses were observed between the first and subsequent cycles. Whereas estradiol production and follicular growth were closely correlated in the first attempt, we recorded a dissociation between these two parameters of ovarian response during subsequent stimulations. Four clinical pregnancies occurred in these nine patients, and there was one abortion. This therapeutic approach can be successfully used to induce ovulation; however, prolonging pituitary suppression between treatment cycles changes the type of ovarian response and is not followed by better results.
9名患有多囊卵巢疾病导致慢性无排卵且对枸橼酸氯米芬治疗无反应的女性，接受了促性腺激素释放激素激动剂（布舍瑞林）以诱导垂体脱敏。4周后，尝试通过逐步增加尿促卵泡素的剂量来诱导排卵。仅在妊娠试验呈阳性时才停止布舍瑞林治疗。首次和随后的周期观察到不同的反应。在首次尝试中，雌二醇产生和卵泡生长密切相关，而在随后的刺激过程中，我们记录到卵巢反应的这两个参数之间出现了分离。这9名患者中有4例临床妊娠，并有1例流产。这种治疗方法可成功用于诱导排卵；然而，延长治疗周期之间的垂体抑制会改变卵巢反应类型，且不会带来更好的结果。
