Venturini P L, Remorgida V, Anserini P, De Cecco L
Department of Obstetrics and Gynecology, University of Genoa, Italy.
Gynecol Endocrinol. 1988 Sep;2(3):205-13. doi: 10.3109/09513599809029345.
A combined regimen based on exogenous gonadotropins followed by pulsatile gonadotropin-releasing hormone was attempted in order to induce ovulation in a group of patients with polycystic ovarian disease. The women were selected on the basis of previous unsuccessful treatment with clomiphene citrate, gonadotropin and pulsatile gonadotropin-releasing hormone used separately. At our first attempt at application of this new approach, in all patients follicular growth was recorded and ovulation was induced with exogenous chorionic gonadotropin, without hyperstimulation. Two clinical pregnancies were established. Retrospective hormonal evaluation showed the presence of two premature luteinizations. Pulsatile gonadotropin-releasing hormone administration following follicular recruitment with exogenous gonadotropin may therefore be considered an effective therapy for polycystic ovarian patients resistant to conventional treatment.
为了诱导一组多囊卵巢疾病患者排卵，尝试了一种基于外源性促性腺激素随后脉冲式给予促性腺激素释放激素的联合治疗方案。这些女性是基于之前单独使用枸橼酸氯米芬、促性腺激素和脉冲式促性腺激素释放激素治疗失败而入选的。在我们首次应用这种新方法时，记录了所有患者的卵泡生长情况，并用外源性绒毛膜促性腺激素诱导排卵，未发生过度刺激。有两例临床妊娠。回顾性激素评估显示存在两次过早黄素化。因此，对于对传统治疗耐药的多囊卵巢患者，在用外源性促性腺激素募集卵泡后给予脉冲式促性腺激素释放激素可能被认为是一种有效的治疗方法。
