Harris Pamela S, Stalam Tapati, Ache Kevin A, Harrold Joan E, Craig Teresa, Teno Joan, Smither Eugenia, Dougherty Meredith, Casarett David
1 Kansas City Hospice and Palliative Care , Kansas City, Missouri.
J Palliat Med. 2014 Aug;17(8):894-8. doi: 10.1089/jpm.2013.0631. Epub 2014 Jun 12.
To determine whether it is possible to predict, at the time of hospice enrollment, which patients will die within 6 months.
Electronic health record-based retrospective cohort study.
Patients admitted to 10 hospices in the CHOICE network (Coalition of Hospices Organized to Investigate Comparative Effectiveness).
Hospice patients.
Mortality at 6 months following hospice admission.
Among 126,620 patients admitted to 10 hospices, 118,532 (93.6%) died within 6 months. In a multivariable logistic regression model, five characteristics were independent predictors of 6-month mortality. For instance, patients younger than 65 years were less likely to die within 6 months (odds ratio [OR] 0.64; 95% confidence interval [CI] 0.45-0.91; p=0.014). Conversely, male patients were more likely to die within 6 months (OR 1.47; 95% CI 1.05-2.02; p=;0.036). After adjusting for other variables in this model, there were several subgroups with a low probability of 6-month probability (e.g., stroke and Palliative Performance Scale [PPS] score=50; adjusted probability of 6-month mortality=39.4%; 95% CI: 13.9%-72.5%). However, 95% confidence intervals of these 6-month mortality predictions extended above 50%.
Hospices might use several variables to identify patients with a relatively low risk for 6-month mortality and who therefore may become ineligible to continue hospice services if they fail to show significant disease progression.
确定在临终关怀登记时能否预测哪些患者会在6个月内死亡。
基于电子健康记录的回顾性队列研究。
CHOICE网络(组织起来调查比较效果的临终关怀联盟)中的10家临终关怀机构收治的患者。
临终关怀患者。
临终关怀入院后6个月的死亡率。
在10家临终关怀机构收治的126,620例患者中,118,532例(93.6%)在6个月内死亡。在多变量逻辑回归模型中,五个特征是6个月死亡率的独立预测因素。例如,65岁以下的患者在6个月内死亡的可能性较小(比值比[OR]0.64;95%置信区间[CI]0.45 - 0.91;p = 0.014)。相反,男性患者在6个月内死亡的可能性更大(OR 1.47;95% CI 1.05 - 2.02;p = 0.036)。在该模型中对其他变量进行调整后,有几个亚组6个月死亡概率较低(例如,中风且姑息治疗表现量表[PPS]评分为50;6个月死亡率的调整概率为39.4%;95% CI:13.9% - 72.5%)。然而,这些6个月死亡率预测的95%置信区间超过了50%。
临终关怀机构可以使用几个变量来识别6个月死亡率相对较低的患者,如果这些患者没有出现明显的疾病进展,可能不再符合继续接受临终关怀服务的条件。