de la Pompa J L, Garcia J R, Ferrús A
Instituto Cajal, CSIC, Madrid, Spain.
Dev Biol. 1989 Feb;131(2):439-54. doi: 10.1016/s0012-1606(89)80016-8.
The different thoracic muscles of Drosophila are affected specifically in the mutants: stripe (sr), erect wing (ewg), vertical wings (vtw), and nonjumper (nj). We have tested the extent of this specificity by means of a genetic analysis of these loci, multiple mutant combinations, and gene dosage experiments. A quantitative, rather than a qualitative, specificity is found in the mutant phenotypes. All muscles are altered by mutations in any given gene, but the severity of these alterations is muscle specific. The locus stripe seems to have a polar organization where different allelic combinations show quantitative specificity in the muscle affected. In addition to the muscle phenotypes, neural alterations are detected in these mutants. The synergism found between ewg, vtw and ewg, sr as well as the dosage effect of the distal end of the X chromosome upon the expression of ewg and sr suggests the existence of functional relationships among the loci analyzed.
条纹（sr）、竖翅（ewg）、垂翅（vtw）和非跳跃者（nj）。我们通过对这些基因座进行遗传分析、多种突变体组合以及基因剂量实验，测试了这种特异性的程度。在突变体表型中发现的是一种定量而非定性的特异性。任何给定基因的突变都会改变所有肌肉，但这些改变的严重程度具有肌肉特异性。基因座条纹似乎具有极性组织，不同的等位基因组合在受影响的肌肉中表现出定量特异性。除了肌肉表型外，在这些突变体中还检测到神经改变。ewg与vtw之间以及ewg与sr之间发现的协同作用，以及X染色体远端对ewg和sr表达的剂量效应，表明所分析的基因座之间存在功能关系。
