Randall J C, Morris D C, Tomita T, Anderson H C
Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 66103.
Hum Pathol. 1989 Jan;20(1):86-8. doi: 10.1016/0046-8177(89)90209-8.
This report describes the case of a 69-year-old man with adenocarcinoma of the transverse colon who developed heterotopic ossification in a metastatic axillary lymph node. The areas of pathologic bone formation were characterized by the appearance of osteoblast-like cells at the surfaces of the mineral deposits. Immunostaining for alkaline phosphatase revealed a significant concentration of this enzyme in these cells and, to a lesser degree, on the apical membrane of the glandular cells of the adenocarcinoma adjacent to the ossification centers. Proliferating mesenchymal cells in close proximity to the areas of osteogenesis also showed significant immunolabeling. We conclude that metastatic colonic carcinoma can promote heterotopic ossification, and that alkaline phosphatase is intimately associated with bone formation under these pathologic conditions.
本报告描述了一名69岁横结肠癌男性患者，其腋窝转移性淋巴结发生了异位骨化。病理性骨形成区域的特征是在矿物质沉积表面出现成骨样细胞。碱性磷酸酶免疫染色显示该酶在这些细胞中大量聚集，在较小程度上也存在于与骨化中心相邻的腺癌腺细胞顶膜上。紧邻骨生成区域的增殖间充质细胞也显示出明显的免疫标记。我们得出结论，转移性结肠癌可促进异位骨化，并且在这些病理条件下碱性磷酸酶与骨形成密切相关。
