Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Anticancer Res. 2014 Jun;34(6):2701-7.
Vascularized bone graft (VBG) is a form of vascularized bone marrow transplant in which the bone marrow is surgically grafted with its microenvironment intact. Due to the preservation of cellular viability, VBG have significant advantages over non-vascularized bone grafts. Free vascularized fibula grafts have superior material properties and tolerate infection. Bone healing can be accomplished in a shorter period, even in an irradiated bed. In addition to these properties, VBG has other biological advantages that are not always familiar to oncological surgeons. Hypertrophic change can be divided into reactive and adaptive hypertrophy. Early hypertrophy is associated with donor-derived cells, whereas later remodeling is associated with recipient-derived cells. VBG has significant advantages in enhancing neo-revascularization of necrotic bone. We reviewed VBG from a novel viewpoint that stems from our basic research.
带血管骨移植（VBG）是一种带血管骨髓移植，其中骨髓在手术中与完整的微环境一起移植。由于细胞活力得以保留，VBG 具有比非血管化骨移植物更大的优势。游离血管化腓骨移植具有更好的材料特性，并且能耐受感染。即使在照射床上，骨愈合也可以在更短的时间内完成。除了这些特性之外，VBG 还有其他生物学优势，这些优势并不总是为肿瘤外科医生所熟悉。肥大可分为反应性和适应性肥大。早期肥大与供体来源的细胞有关，而后期的重塑则与受体来源的细胞有关。VBG 在增强坏死骨的新生血管化方面具有显著优势。我们从我们的基础研究中提出了一个新的观点来回顾 VBG。
