Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland.
Anticancer Res. 2014 Jun;34(6):2833-40.
BACKGROUND/AIM: It has been shown that HSPA2 protein, a testis-enriched member of HSPA/HSP70 family, is important for cancer cell growth and metastasis. However, the status of HSPA2 expression in tumors and its clinical/prognostic significance are obscure. Herein we aimed to investigate the expression of HSPA2 in various types of tumors and to determine the possible clinical and prognostic significance of HSPA2 in non-small cell lung carcinoma (NSCLC).
Tissue microarrays and postoperative NSCLC tumors were tested for HSPA2 by immunohistochemistry.
HSPA2 is expressed in the majority of tumor histotypes. In NSCLC patients (n=85), nuclear HSPA2 expression was associated with histology, TNM staging and prognosis. High HSPA2 expression was significantly related to shorter overall survival (OS) in stage I-II patients. In multivariate analysis, high HSPA2, together with stage IIIA and male sex, were associated with shorter OS in the whole group.
As exemplified in NSCLC the status of HSPA2 in human tumors may have certain prognostic significance.
背景/目的：已经证实，HSPA2 蛋白是 HSP70 家族中富含睾丸的成员，对癌细胞的生长和转移很重要。然而，肿瘤中 HSPA2 表达的状况及其临床/预后意义尚不清楚。在此，我们旨在研究 HSPA2 在各种类型肿瘤中的表达，并确定 HSPA2 在非小细胞肺癌（NSCLC）中的可能临床和预后意义。
通过免疫组织化学检测组织微阵列和术后 NSCLC 肿瘤中的 HSPA2。
HSPA2 在大多数肿瘤组织类型中表达。在 NSCLC 患者（n=85）中，核 HSPA2 表达与组织学、TNM 分期和预后相关。高 HSPA2 表达与 I 期-II 期患者的总生存期（OS）较短显著相关。多因素分析表明，在整个组中，高 HSPA2 与 IIIA 期和男性性别与较短的 OS 相关。
正如在 NSCLC 中所举例说明的那样，人类肿瘤中 HSPA2 的状态可能具有一定的预后意义。
