胰岛素样生长因子受体 1 mRNA 表达作为晚期非小细胞肺癌的预后标志物。
Insulin-like growth factor receptor 1 mRNA expression as a prognostic marker in advanced non-small cell lung cancer.
机构信息
Department of Oncology, Finsen Centre, National University Hospital, Copenhagen, Denmark Laboratory of Pharmacogenomics, Division of Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Department of Pathology, Diagnostic Centre, National University Hospital, Copenhagen, Denmark.
出版信息
Anticancer Res. 2014 Jun;34(6):2991-6.
BACKGROUND
The insulin-like growth factor 1 receptor (IGF1R) has yet to be established as a biomarker in non-small cell lung cancer (NSCLC) but could prove useful in customized chemotherapy. We explored its prognostic value using both quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC).
MATERIALS AND METHODS
Analyses of IGF1R were performed on patients with advanced NSCLC, included in a randomized chemotherapy trial, having large, representative tissue samples. IGF1R mRNA and protein expression were correlated to clinical end-points.
RESULTS
Surgical tissue samples were available from 33 patients deemed inoperable. IGF1R status varied according to histopathology. Patients with tumors positive for IGF1R mRNA expression had a shorter progression-free and overall survival when compared to the negative sub-group (6.1 vs. 7.4 months, p=0.039 and 10.9 vs. 14.3 months, p=0.038, respectively). IGF1R protein expression showed a similar, although non-significant tendency.
CONCLUSION
IGF1R mRNA expression may be a prognostic biomarker in advanced NSCLC and should be investigated in a larger population.
背景
胰岛素样生长因子 1 受体（IGF1R）尚未被确立为非小细胞肺癌（NSCLC）的生物标志物，但在定制化疗中可能有用。我们使用定量实时逆转录聚合酶链反应（qRT-PCR）和免疫组织化学（IHC）来探索其预后价值。
材料与方法
对纳入随机化疗试验的晚期 NSCLC 患者进行 IGF1R 分析，这些患者具有大的、有代表性的组织样本。IGF1R mRNA 和蛋白表达与临床终点相关联。
结果
从被认为不可手术的 33 名患者中获得了手术组织样本。根据组织病理学，IGF1R 状态存在差异。与阴性亚组相比，IGF1R mRNA 表达阳性的肿瘤患者的无进展生存期和总生存期更短（6.1 与 7.4 个月，p=0.039 和 10.9 与 14.3 个月，p=0.038）。IGF1R 蛋白表达也显示出类似的趋势，但无统计学意义。
结论
IGF1R mRNA 表达可能是晚期 NSCLC 的预后生物标志物，应在更大的人群中进行研究。
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