Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan.
Ann Surg Oncol. 2012 Jul;19 Suppl 3:S412-20. doi: 10.1245/s10434-011-1878-x. Epub 2011 Jul 6.
The insulin-like growth factor 1 receptor (IGF1R) is widely expressed in normal tissues and many malignancies in humans. We investigated the clinical significance of the expression of the IGF1R gene in human lung adenocarcinoma.
A total of 238 patients with lung adenocarcinoma were investigated. Quantitative real-time reverse-transcription polymerase chain reaction (RT-PCR) assays were performed to evaluate the gene expression of IGF1R, and immunohistochemical staining was done to evaluate the protein expression of IGF1R.
Among the 238 patients with lung adenocarcinoma, 107 tumors (45.0%) were IGF1R-low and 131 tumors (55.0%) were IGF1R-high. The IGF1R gene expression ratio was significantly lower in moderately to poorly differentiated adenocarcinomas than in well-differentiated adenocarcinomas (P = 0.0388). Gene expression of IGF1R was significantly correlated with protein expression of IGF1R (r = 0.7163, P < 0.0001). Regarding patient survival, overall survival was significantly lower in patients with IGF1R-low tumors than in those with IGF1R-high tumors (63.2% versus 76.1% 5-year survival, P = 0.0188). Multivariate analysis using a Cox proportional-hazards model demonstrated that IGF1R gene status was a significant prognostic factor predicting overall survival of patients with lung adenocarcinoma (hazard ratio 1.800; P = 0.0321). Moreover, the disease-free survival rate was significantly lower in patients with IGF1R-low tumors than in those with IGF1R-high tumors (49.2% versus 64.6% 5-year survival, P = 0.0084).
The present study suggests the level of IGF1R expression to be a useful prognostic marker for patients with dedifferentiated lung adenocarcinoma.
胰岛素样生长因子 1 受体（IGF1R）在正常组织和人类许多恶性肿瘤中广泛表达。我们研究了 IGF1R 基因在人类肺腺癌中的表达的临床意义。
共检测了 238 例肺腺癌患者。采用定量实时逆转录聚合酶链反应（RT-PCR）检测 IGF1R 基因的表达，采用免疫组织化学染色检测 IGF1R 蛋白的表达。
在 238 例肺腺癌患者中，107 例肿瘤（45.0%）为 IGF1R-低表达，131 例肿瘤（55.0%）为 IGF1R-高表达。中-低分化腺癌的 IGF1R 基因表达比值明显低于高分化腺癌（P = 0.0388）。IGF1R 基因表达与 IGF1R 蛋白表达显著相关（r = 0.7163，P < 0.0001）。关于患者生存情况，IGF1R-低表达肿瘤患者的总生存率明显低于 IGF1R-高表达肿瘤患者（5 年生存率分别为 63.2%和 76.1%，P = 0.0188）。采用 Cox 比例风险模型的多因素分析表明，IGF1R 基因状态是预测肺腺癌患者总生存的显著预后因素（风险比 1.800；P = 0.0321）。此外，IGF1R-低表达肿瘤患者的无病生存率明显低于 IGF1R-高表达肿瘤患者（5 年生存率分别为 49.2%和 64.6%，P = 0.0084）。
本研究表明 IGF1R 表达水平可作为分化型肺腺癌患者的有用预后标志物。
