Tan Wen-Nee, Khairuddean Melati, Wong Keng-Chong, Khaw Kooi-Yeong, Vikneswaran Murugaiyah
School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
Fitoterapia. 2014 Sep;97:261-7. doi: 10.1016/j.fitote.2014.06.003. Epub 2014 Jun 9.
A triflavanone, Garcineflavanone A (1) and a biflavonol, Garcineflavonol A (2) have been isolated from the stem bark of Garcinia atroviridis (Clusiaceae), collected in Peninsular Malaysia. Their structures were established using one and two-dimensional NMR, UV, IR and mass spectrometry and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. Molecular docking studies of the isolated compounds were performed using docking procedure of AutoDock to disclose the binding interaction and orientation of these molecules into the active site gorge.
从采集于马来西亚半岛的山竹（藤黄科）茎皮中分离出了一种三黄酮，藤黄三黄酮A（1）和一种双黄酮醇，藤黄双黄酮醇A（2）。通过一维和二维核磁共振、紫外、红外和质谱确定了它们的结构，并对其体外乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）的抑制活性进行了评估。使用AutoDock对接程序对分离出的化合物进行分子对接研究，以揭示这些分子在活性位点峡谷中的结合相互作用和取向。
